Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
J Vet Med Sci. 2022 Jun 18;84(6):872-876. doi: 10.1292/jvms.22-0076. Epub 2022 May 5.
Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs.
增生的杯状细胞和丰富的黏液是迷你腊肠犬炎性结直肠息肉（ICRPs）的显著特征。在这项研究中，评估了患有 ICRPs 的迷你腊肠犬和健康犬的选定黏蛋白基因表达和杯状细胞比例。各组之间 MUC2 基因表达无显著差异，而 MUC5AC 基因表达在息肉病变中明显高于健康结肠黏膜。尽管上隐窝区域的杯状细胞百分比在各组之间无显著差异，但在息肉病变中明显降低。总之，MUC5AC 基因表达增加和杯状细胞比例变化可能与 ICRPs 的发病机制有关。
