CD8调节性T细胞杀死致病细胞以避免自身免疫。

CD8 Tregs kill pathogenic cells to avert autoimmunity.

作者信息

Hu Dan, Murugaiyan Gopal

机构信息

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

出版信息

Trends Immunol. 2022 Jun;43(6):415-416. doi: 10.1016/j.it.2022.04.006. Epub 2022 May 5.

DOI:10.1016/j.it.2022.04.006

PMID:35527183

Abstract

Mouse Ly49CD8 regulatory T cells (Tregs) can subdue autoreactive CD4 T cells to suppress autoimmunity. Recently, Li et al. demonstrated that killer-cell immunoglobulin-like receptor (KIR)CD8 T cells are the human equivalent of Ly49CD8 regulatory T cells and kill pathogenic CD4 T cells, which can be increased in certain human autoimmune diseases and viral infections.

摘要

小鼠Ly49CD8调节性T细胞（Tregs）能够抑制自身反应性CD4 T细胞，从而抑制自身免疫。最近，李等人证明，杀伤细胞免疫球蛋白样受体（KIR）CD8 T细胞相当于人类的Ly49CD8调节性T细胞，可杀伤致病性CD4 T细胞，在某些人类自身免疫性疾病和病毒感染中，这种细胞数量会增加。