Ma T T, He N, Wang H T, Chen Y L, Zhuang Y, Shi H Y, Lan T F, Guo M Y, Yu R L, Wang Y, Wang X Y
Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Department of Allergy, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Apr 7;57(4):479-484. doi: 10.3760/cma.j.cn115330-20210701-00416.
To investigate the sensitization characteristics of Juniperus chinensis pollen in patients with allergic rhinitis and/or allergic asthma in Beijing area, and to explore the characteristics of Juniper chinensis pollen sensitized population. Patients with suspected allergic rhinitis and/or asthma from January 2017 to December 2019 in the outpatient department of Allergy Department of Beijing Shijitan Hospital were selected in this study. Skin prick test (SPT) was performed with Juniper chinensis pollen allergen reagent to compare different age and disease allergen distribution, and to observe the sensitization characteristics of its population. All of the analyses were performed using SAS software version 9.4. A total of 8 380 patients were enrolled in the end. The total positive rate of Juniper chinensis pollen SPT reached 49.92% (4 183/8 380). The positive rate of Juniper chinensis pollen SPT was highest in the 10-14 age group, reaching 60.99% (283/464). Compared with other age groups, there was a statistical difference (χ²=266.77, <0.01). The SPT positive rate of patients aged less than 10 years increased with the increase of age, while the SPT positive rate of patients aged over 40 years decreased with the increase of age. Single Juniper chinensis pollen was less allergenic, accounting for about 25.05% (1 048/4 183), and the patients' age was (35.21±12.39) years. Regardless of single Juniper chinensis pollen or other pollen allergies, allergic rhinitis was the main disease. Among the patients with SPT positive Juniper chinensis pollen combined with other inhaled pollen allergens, willow pollen accounted for the first (74.99%). The positive rate of Juniper chinensis pollen was the highest in patients with single allergic rhinitis, accounting for 52.05% (3 797/7 295), and the rate in patients with single allergic asthma was the lowest, accounting for 17.49% (53/303), with statistically difference (χ²=138.99, <0.01). Juniper chinensis pollen is highly sensitized in patients with allergic rhinitis and/or allergic asthma in Beijing . The positive rate of SPT is highest among 10-14 age group, most of which showed strong positive reaction, and allergic rhinitis is more common in Juniper chinensis pollen sensitization diseases.
为研究北京地区变应性鼻炎和/或变应性哮喘患者中桧柏花粉的致敏特征，并探讨桧柏花粉致敏人群的特点。本研究选取2017年1月至2019年12月在北京世纪坛医院变态反应科门诊就诊的疑似变应性鼻炎和/或哮喘患者。采用桧柏花粉变应原试剂进行皮肤点刺试验（SPT），比较不同年龄和疾病的变应原分布情况，观察其人群的致敏特征。所有分析均使用SAS 9.4软件进行。最终共纳入8380例患者。桧柏花粉SPT总阳性率达49.92%（4183/8380）。桧柏花粉SPT阳性率在10 - 14岁年龄组最高，达60.99%（283/464）。与其他年龄组相比，差异有统计学意义（χ² = 266.77，P < 0.01）。10岁以下患者SPT阳性率随年龄增长而升高，40岁以上患者SPT阳性率随年龄增长而降低。单纯桧柏花粉致敏性较低，占约25.05%（1048/4183），患者年龄为（35.21±12.39）岁。无论单纯桧柏花粉还是合并其他花粉过敏，变应性鼻炎都是主要疾病。在桧柏花粉SPT阳性且合并其他吸入性花粉变应原的患者中，柳树花粉占首位（74.99%）。单纯变应性鼻炎患者中桧柏花粉阳性率最高，占52.05%（3797/7295），单纯变应性哮喘患者中阳性率最低，占17.49%（53/303），差异有统计学意义（χ² = 138.99，P < 0.01）。北京地区变应性鼻炎和/或变应性哮喘患者中桧柏花粉致敏率较高。SPT阳性率在10 - 14岁年龄组最高，多数表现为强阳性反应，变应性鼻炎在桧柏花粉致敏疾病中更为常见。
