Fu Yu, Song Yi-Lai, Liu Zhong-Guo
Drug Clinical Trial Unit, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
World J Clin Cases. 2024 Nov 6;12(31):6451-6461. doi: 10.12998/wjcc.v12.i31.6451.
Allergic rhinitis (AR) poses a significant global health burden, with the potential to progress to asthma, thereby impacting patients' quality of life. Immunotherapy has demonstrated effectiveness in mitigating clinical symptoms by altering the underlying disease mechanisms of AR. This article provides a thorough review of the current state of immunotherapy for AR, encompassing various facets of immunotherapeutic strategies, elucidating their mechanisms and clinical implications. By presenting a nuanced understanding of the present landscape of immunotherapy for AR, this review aims to serve as a valuable reference for informing clinical treatment strategies. The subsequent analysis of diverse immunotherapeutic pathways offers a comprehensive understanding of their mechanisms and clinical implications. A meticulous examination is conducted on subcutaneous immunotherapy, sublingual immunotherapy, oral immunotherapy, intralymphatic immunotherapy, and innovative intravenous gold-induced autologous serum injection therapy. Each pathway is systematically elucidated, with its distinctive features and potential contributions to managing AR emphasized. In conclusion, synthesizing epidemiological insights, immunotherapeutic nuances, and pathway-specific analyses encapsulates a profound understanding of immunotherapy for AR.
变应性鼻炎（AR）给全球健康带来了重大负担，有可能发展为哮喘，从而影响患者的生活质量。免疫疗法已证明可通过改变AR的潜在疾病机制来减轻临床症状。本文全面综述了AR免疫疗法的现状，涵盖免疫治疗策略的各个方面，阐明其机制和临床意义。通过对AR免疫疗法的现状进行细致入微的解读，本综述旨在为临床治疗策略提供有价值的参考。随后对多种免疫治疗途径的分析有助于全面了解其机制和临床意义。对皮下免疫疗法、舌下免疫疗法、口服免疫疗法、淋巴管内免疫疗法以及创新的静脉注射金诱导自体血清注射疗法进行了细致研究。对每种途径进行了系统阐述，强调了其独特特征以及对AR治疗的潜在贡献。总之，综合流行病学见解、免疫治疗细微差别和特定途径分析，体现了对AR免疫疗法的深刻理解。
