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在双功能有机催化剂存在下轴向手性氰基芳烃的对映选择性溴化反应。

Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts.

作者信息

Wada Yuuki, Matsumoto Akira, Asano Keisuke, Matsubara Seijiro

机构信息

Department of Material Chemistry, Graduate School of Engineering, Kyoto University Kyotodaigaku-Katsura, Nishikyo Kyoto 615-8510 Japan

出版信息

RSC Adv. 2019 Oct 4;9(54):31654-31658. doi: 10.1039/c9ra05532k. eCollection 2019 Oct 1.

DOI:10.1039/c9ra05532k
PMID:35527922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072646/
Abstract

Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities.

摘要

报道了使用双功能有机催化剂对具有高固有旋转势垒的轴向手性氰基芳烃进行对映选择性溴化及动态动力学拆分。在优化温度下分几份顺序加入溴化试剂，对于实现高对映选择性是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/3a7901f33bc8/c9ra05532k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/45b2a4cc0e1b/c9ra05532k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/f9a0106ff51e/c9ra05532k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/a193b870e394/c9ra05532k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/a72e2b72c684/c9ra05532k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/f0e279c528da/c9ra05532k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/9eb77a9c0e00/c9ra05532k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/3a7901f33bc8/c9ra05532k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/45b2a4cc0e1b/c9ra05532k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/f9a0106ff51e/c9ra05532k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/a193b870e394/c9ra05532k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/a72e2b72c684/c9ra05532k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/f0e279c528da/c9ra05532k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/9eb77a9c0e00/c9ra05532k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c02/9072646/3a7901f33bc8/c9ra05532k-s3.jpg

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