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石墨烯量子点介导的DNA碱基对中的电子转移。

Graphene quantum dots mediated electron transfer in DNA base pairs.

作者信息

Liu Chang, Guo Linqing, Zhang Biao, Lu Liping

机构信息

Key Laboratory of Beijing on Regional Air Pollution Control, Beijing University of Technology Beijing 100124 China

出版信息

RSC Adv. 2019 Oct 4;9(54):31636-31644. doi: 10.1039/c9ra05481b. eCollection 2019 Oct 1.

DOI:10.1039/c9ra05481b
PMID:35527930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072722/
Abstract

Graphene quantum dots (GQDs) were connected to [Ru(bpy)] to sense DNA-mediated charge transfer. Interaction between abasic site double stranded DNA (Abasic-DNA) and [Ru(bpy)-GQD] was investigated by absorption spectroscopy, gel electrophoresis, circular dichroism, and melting temperature measurements. The results indicate that [Ru(bpy)-GQD] could be intercalated into double stranded DNA. Using [Ru(bpy)-GQD] as a signal molecule, the charge transfer performance of DNA-intercalated [Ru(bpy)-GQD] was determined using electrochemical and electrochemiluminescence measurements. Various DNA types were immobilized on Au electrodes Au-S bonds. Electrochemiluminescence and electrochemical measurements indicate that [Ru(bpy)-GQD] could enhance DNA-mediated charge transfer when intercalated into an abasic site of double stranded DNA. And comparing with [Ru(bpy)], it can be concluded that GQDs intercalate into the DNA duplex by acting as a base analog, thus enhancing DNA charge transfer. These findings suggest that the DNA-GQD structure could aid the development of molecular devices and electric drivers, and broaden the application of DNA charge transfer.

摘要

石墨烯量子点（GQDs）与[Ru(bpy)]相连以检测DNA介导的电荷转移。通过吸收光谱、凝胶电泳、圆二色性和熔解温度测量研究了无碱基位点双链DNA（无碱基DNA）与[Ru(bpy)-GQD]之间的相互作用。结果表明，[Ru(bpy)-GQD]可以插入双链DNA中。以[Ru(bpy)-GQD]作为信号分子，通过电化学和电化学发光测量确定了DNA插入的[Ru(bpy)-GQD]的电荷转移性能。通过Au-S键将各种类型的DNA固定在金电极上。电化学发光和电化学测量表明，当[Ru(bpy)-GQD]插入双链DNA的无碱基位点时，它可以增强DNA介导的电荷转移。与[Ru(bpy)]相比，可以得出结论，GQDs通过作为碱基类似物插入DNA双链体中，从而增强DNA电荷转移。这些发现表明，DNA-GQD结构有助于分子器件和电驱动器的开发，并拓宽了DNA电荷转移的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/af4b9e93fb0c/c9ra05481b-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/2a353efe4044/c9ra05481b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/f9bf441eb7da/c9ra05481b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/e99d66c1ea76/c9ra05481b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/5740ce5e5bab/c9ra05481b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/9d1122c53611/c9ra05481b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/c4fc91c3cdca/c9ra05481b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/0a7bbc2371cc/c9ra05481b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/756b0161433c/c9ra05481b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/af4b9e93fb0c/c9ra05481b-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/2a353efe4044/c9ra05481b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/f9bf441eb7da/c9ra05481b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/e99d66c1ea76/c9ra05481b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/5740ce5e5bab/c9ra05481b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/9d1122c53611/c9ra05481b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/c4fc91c3cdca/c9ra05481b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/0a7bbc2371cc/c9ra05481b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/756b0161433c/c9ra05481b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/9072722/af4b9e93fb0c/c9ra05481b-f8.jpg

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