Abb Sabine, Tarrat Nathalie, Cortés Juan, Andriyevsky Bohdan, Harnau Ludger, Schön J Christian, Rauschenbach Stephan, Kern Klaus
Max Planck Institute for Solid State Research Heisenbergstr. 1 70569 Stuttgart Germany
CEMES, Université de Toulouse, CNRS 29 Rue Jeanne Marvig 31055 Toulouse France.
RSC Adv. 2019 Nov 4;9(61):35813-35819. doi: 10.1039/c9ra06764g. eCollection 2019 Oct 31.
Saccharides, also commonly known as carbohydrates, are ubiquitous biomolecules, but little is known about their interaction with surfaces. Soft-landing electrospray ion beam deposition in conjunction with high-resolution imaging by scanning tunneling microscopy now provides access to the molecular details of the surface assembly of this important class of bio-molecules. Among carbohydrates, the disaccharide trehalose is outstanding as it enables strong anhydrobiotic effects in biosystems. This ability is closely related to the observed polymorphism. In this work, we explore the self-assembly of trehalose on the Cu(100) surface. Molecular imaging reveals the details of the assembly properties in this reduced symmetry environment. Already at room temperature, we observe a variety of self-assembled motifs, in contrast to other disaccharides like sucrose. Using a multistage modeling approach, we rationalize the conformation of trehalose on the copper surface as well as the intermolecular interactions and the self-assembly behavior.
糖类，通常也被称为碳水化合物，是普遍存在的生物分子，但人们对它们与表面的相互作用知之甚少。软着陆电喷雾离子束沉积结合扫描隧道显微镜的高分辨率成像，现在能够深入了解这类重要生物分子在表面组装的分子细节。在碳水化合物中，二糖海藻糖表现突出，因为它能在生物系统中产生强大的抗脱水作用。这种能力与观察到的多态性密切相关。在这项工作中，我们探索了海藻糖在Cu(100)表面的自组装。分子成像揭示了在这种降低对称性的环境中组装特性的细节。与蔗糖等其他二糖不同，即使在室温下，我们也观察到了多种自组装图案。使用多阶段建模方法，我们解释了海藻糖在铜表面的构象以及分子间相互作用和自组装行为。
