Chen Shuchen, Duan He, Zhang Dewei, Sun Gongping
Medical Oncology Department of Thoracic Cancer 1, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042 Liaoning Province, China.
Department of the Third General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032 Liaoning Province, China.
J Oncol. 2022 Apr 28;2022:3458420. doi: 10.1155/2022/3458420. eCollection 2022.
Although the effects of methylation of the Ras association domain-containing protein 1 isoform A () gene in cell-free DNA on the outcomes of patients with different types of cancer have been reported, the results are inconsistent.
: To explore the relationships between methylation in cell-free DNA and the outcomes of cancer patients.
The PubMed, Embase, and Web of Science databases were searched for papers related to this topic on December 8, 2021. The retrieved articles were screened by two independent researchers, following which the methodological quality of the selected studies was evaluated using the Newcastle-Ottawa Scale. Additionally, hazard ratios were calculated, and publication bias of the studies was determined using Egger's test.
Nine relevant publications involving a combined total of 1254 patients with different types of cancer were included in this study. The combined results of the random effects models yielded a hazard ratio of 1.73 (95% confidence interval: 1.31, 2.29; < 0.001), which suggested there was a significant association between methylation and overall survival, and patients with an methylation status had a significantly increased risk of total death. Moreover, the Egger test result suggested there was no significant publication bias among the included studies.
The methylation of in cell-free DNA in cancer patients was observably associated with an increased risk of poor overall survival.
尽管已有报道称游离DNA中含Ras关联结构域蛋白1亚型A（）基因的甲基化对不同类型癌症患者的预后有影响，但其结果并不一致。
探讨游离DNA中的甲基化与癌症患者预后之间的关系。
于2021年12月8日检索PubMed、Embase和Web of Science数据库中与该主题相关的论文。由两名独立研究人员对检索到的文章进行筛选，随后使用纽卡斯尔-渥太华量表评估所选研究的方法学质量。此外，计算风险比，并使用Egger检验确定研究的发表偏倚。
本研究纳入了9篇相关文献，共涉及1254例不同类型癌症患者。随机效应模型的合并结果显示风险比为1.73（95%置信区间：1.31，2.29；<0.001），这表明甲基化与总生存期之间存在显著关联，甲基化状态的患者总死亡风险显著增加。此外，Egger检验结果表明纳入的研究之间不存在显著的发表偏倚。
癌症患者游离DNA中的甲基化与总体生存不良风险增加明显相关。
