Gupta Gaurav, Shareef Imtiyaz, Tomar Shalini, Kumar Mylathal Sivasamy Naveen, Pandey Shivam, Sarda Radhika, Singh Ravinder, Das Bimal Kumar, Sinha Sanjeev
Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Natl Acad Sci Lett. 2022;45(4):363-369. doi: 10.1007/s40009-022-01123-9. Epub 2022 May 4.
To characterize Th1/Th2/Th17 cytokine profile (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A) among different stages of COVID-19 infection.
This was a cross-sectional study which included six healthy individuals and 68 patients who were admitted with COVID-19 in the Department of Medicine, at All India Institute of Medical Sciences, New Delhi, from July 2020 to September 2020. Patients were categorized into mild, moderate, and severe COVID-19 groups, and serum samples were drawn for the measurement of Th1/Th2/Th17 cytokines (IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A) which was done by BD™ Cytometric Bead Array.
All the cytokines showed dynamic expression in the COVID-19 group, of which only IL-6 was statistically significant. Among the three severity groups of COVID-19, increased severity did not transform into increased cytokine level, with the exception for IL-6, which was statistically significant.
In our small sample study, six cytokines expressions were evaluated however most of them were elevated in COVID-19 patients but were not statistically significant except IL-6.
描述新型冠状病毒肺炎（COVID-19）感染不同阶段的Th1/Th2/Th17细胞因子谱（白细胞介素-2（IL-2）、IL-4、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）和IL-17A）。
这是一项横断面研究，纳入了2020年7月至2020年9月在新德里全印度医学科学研究所医学科收治的6名健康个体和68例COVID-19患者。患者被分为轻度、中度和重度COVID-19组，并采集血清样本，通过BD™细胞计数微珠阵列检测Th1/Th2/Th17细胞因子（IL-4、IL-6、IL-10、TNF-α、IFN-γ和IL-17A）。
所有细胞因子在COVID-19组均呈动态表达，其中只有IL-6具有统计学意义。在COVID-19的三个严重程度组中，除IL-6具有统计学意义外，严重程度增加并未转化为细胞因子水平升高。
在我们的小样本研究中，评估了六种细胞因子的表达，然而在COVID-19患者中大多数细胞因子表达升高，但除IL-6外均无统计学意义。
