Shirvani Fariba, Fattahi Mahsa
Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Curr Med Mycol. 2021 Sep;7(3):9-12. doi: 10.18502/cmm.7.3.7799.
The present study was performed to raise attention on the frequency of spp. and evaluation of risk factors of candiduria in neonates and children.
In total, 60 urine samples were collected from the suspected neonates and children. Identification of at species level was performed using the polymerase chain reaction-restriction fragment length polymorphism approach.
The restriction fragment length polymorphism fingerprint analysis revealed that (n=17; 28.33 %) is the most prevalent isolated species followed by (n=9; 15%), (n=4; 9.52%), and (n=2; 4.76%). All of the and complex strains were identified as with gene primers and using the restriction enzyme activity, respectively. In this study, none of the mentioned factors was the cause of infection, but they could be considered risk factors. The mean hospital stay was 21 days (range: 7-21 days). More than 90% of the patients had a urinary catheter, and about 26% of them received antibiotics. Regarding the risk factors, there was no significant difference between the two groups of candidiasis in terms of and non-albicans (<0.01).
Candiduria has always been a challenging issue, especially in children admitted to hospitals. Outcome of candiduria in patients with generally healthy is little.
本研究旨在提高对新生儿和儿童念珠菌属频率的关注以及对念珠菌尿症危险因素的评估。
总共从疑似新生儿和儿童中收集了60份尿液样本。使用聚合酶链反应-限制性片段长度多态性方法在种水平上对念珠菌进行鉴定。
限制性片段长度多态性指纹分析显示，白色念珠菌（n = 17；28.33%）是最常见的分离菌种，其次是光滑念珠菌（n = 9；15%）、热带念珠菌（n = 4；9.52%）和近平滑念珠菌（n = 2；4.76%）。所有白色念珠菌和光滑念珠菌复合菌株分别使用白色念珠菌基因引物和利用EcoRI限制性内切酶活性被鉴定为白色念珠菌。在本研究中，上述因素均不是感染原因，但可被视为危险因素。平均住院时间为21天（范围：7 - 21天）。超过90%的患者留置导尿管，约26%的患者接受了抗生素治疗。关于危险因素，白色念珠菌和非白色念珠菌两组念珠菌病之间在留置导尿管和使用抗生素方面无显著差异（P<0.01）。
念珠菌尿症一直是一个具有挑战性的问题，尤其是在住院儿童中。一般健康患者的念珠菌尿症预后较差。
