从肾移植受者尿液中分离出的念珠菌菌种鉴定
Identification of Species Isolated from Renal Transplant Recipients with Candiduria.
作者信息
Yazdani M R, Foroughifar E, Mohammadi R
机构信息
Department of Infectious Diseases, Al-Zahra hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Organ Transplant Med. 2016;7(4):206-211. Epub 2016 Nov 1.
BACKGROUND
Renal transplantation has long been considered the gold standard medical care for patients with end-stage renal disease. Candiduria continue to be a significant complication for renal transplant recipients. The risk of infections depends on the amount of immunosuppression and exposure to the potential pathogens.
OBJECTIVE
Molecular identification of species isolated from renal transplant recipients with candiduria.
METHODS
Between 2009 and 2014, 62 isolates were collected from 485 renal transplant recipients. All isolates were identified by PCR-RFLP profiles after digestion with the restriction enzyme I.
RESULTS
(44%) and complex (5%) had the most and the least prevalence, respectively. Male to female ratio was 26/36, ranging in age from 19 to 62 years.
CONCLUSION
Due to the fact that candiduria is connected with increased mortality in renal transplant recipients, precise identification of species by molecular techniques can lead to an appropriate therapy among high risk patients. remains the most prevalent species isolated from renal transplant recipients, Nevertheless, the number of non- species looks to be emerging.
背景
长期以来，肾移植一直被视为终末期肾病患者的金标准医疗手段。念珠菌尿症仍是肾移植受者的一个重要并发症。感染风险取决于免疫抑制的程度以及接触潜在病原体的情况。
目的
对从患有念珠菌尿症的肾移植受者中分离出的菌种进行分子鉴定。
方法
在2009年至2014年期间，从485名肾移植受者中收集了62株分离株。在用限制性内切酶I消化后，通过PCR-RFLP图谱对所有分离株进行鉴定。
结果
（44%）和复合体（5%）的患病率分别最高和最低。男女比例为26/36，年龄在19岁至62岁之间。
结论
由于念珠菌尿症与肾移植受者死亡率增加有关，通过分子技术精确鉴定菌种可导致对高危患者进行适当治疗。仍是从肾移植受者中分离出的最常见菌种，然而，非菌种的数量似乎正在增加。
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