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氨基硼二吡咯作为用于监测药物释放的比率荧光传感器或用于分子电子学的“电源”选择器。

Amino-BODIPY as the ratiometric fluorescent sensor for monitoring drug release or "power supply" selector for molecular electronics.

作者信息

Porubský Martin, Gurská Soňa, Stanková Jarmila, Hajdúch Marián, Džubák Petr, Hlaváč Jan

机构信息

Department of Organic Chemistry, Faculty of Science, Palacký University Tr. 17. Listopadu 12 771 46 Olomouc Czech Republic

Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Hněvotínská 5 779 00 Olomouc Czech Republic.

出版信息

RSC Adv. 2019 Aug 13;9(43):25075-25083. doi: 10.1039/c9ra03472b. eCollection 2019 Aug 8.

DOI:10.1039/c9ra03472b
PMID:35528670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069925/
Abstract

The glutathione cleavable conjugates of amino-BODIPY dye with model drugs have been tested for monitoring the drug release ratiometric fluorescence based on two excitation and one emission wavelength. As a self-immolative linker was used for the construction of conjugates, free amino-BODIPY was released with the drug. Different excitation profiles of the dye before and after conjugate cleavage and similar emission wavelengths that enabled monitoring the release of the drug the OFF-ON effect were successfully tested inside the cancer cells. UV/Vis spectrometry could be used in the quantification of the conjugate/drug in an analyte irrespective of the cleavage grade. As the system functionality was based only on the altered acylamino-BODIPY present in the conjugate to amino-BODIPY released during the cleavage, the method could be applied as a ratiometric fluorescence theranostic system to other non-fluorescent drugs. Moreover, the present conjugates demonstrated their potential application in molecular electronics as a "power supply" selector enabling the application of two power sources for one "bulb" to maintain its light intensity.

摘要

已对氨基 - BODIPY染料与模型药物的谷胱甘肽可裂解共轭物进行了测试，以基于两个激发波长和一个发射波长监测药物释放的比率荧光。由于使用了自牺牲连接子来构建共轭物，游离氨基 - BODIPY与药物一起释放。共轭物裂解前后染料的不同激发谱以及相似的发射波长使得能够监测药物释放，即“关 - 开”效应，已在癌细胞内成功测试。紫外/可见光谱法可用于分析物中共轭物/药物的定量，而与裂解程度无关。由于该系统功能仅基于共轭物中存在的酰基氨基 - BODIPY在裂解过程中释放为氨基 - BODIPY的变化，该方法可作为比率荧光诊疗系统应用于其他非荧光药物。此外，目前的共轭物在分子电子学中展示了其作为“电源”选择器的潜在应用，能够为一个“灯泡”应用两个电源以维持其光强度。

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