彩色多普勒超声联合甲状腺自身抗体检测在甲状腺癌早期诊断中的应用价值。
Application Value of Color Doppler Ultrasonography Combined with Thyroid Autoantibody Tests in Early Diagnosis of Thyroid Cancer.
机构信息
Department of Ultrasound, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518020 Guangdong, China.
Department of Radiology, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518020 Guangdong, China.
出版信息
Comput Math Methods Med. 2022 Apr 27;2022:5248230. doi: 10.1155/2022/5248230. eCollection 2022.
OBJECTIVE
To explore the application value of color Doppler ultrasonography combined with thyroid autoantibody tests in the early diagnosis of thyroid cancer.
METHODS
The medical data of 100 patients with thyroid nodules treated in our hospital from June 2019 to June 2021 were retrospectively analyzed; all patients received color Doppler ultrasonography and thyroid autoantibody tests before surgery and were divided into the benign lesion group ( = 45) and the malignant lesion group ( = 55) according to the postoperative pathological findings (the gold standard), so as to compare and analyze the application value of color Doppler ultrasonography, thyroid autoantibody tests, and their combination in the early diagnosis of thyroid cancer.
RESULTS
Compared with the pathological findings, the accuracy rate, sensitivity, specificity, positive predictive value, and negative predictive value of the combined diagnosis were significantly higher than those in the single diagnosis of color Doppler ultrasonography, TgAb test, TPOAb test, and TRAb test ( < 0.05), and by plotting the ROC curves to analyze the effect of these modalities in diagnosing early thyroid diseases, the results showed that the areas under the curve from large to small were combined diagnosis, color Doppler ultrasonography, TgAb test, TPOAb test, and TRAb test.
CONCLUSION
Color Doppler ultrasonography has many advantages in the diagnosis of thyroid nodules, such as easy operation, painlessness, noninvasiveness, high efficiency, and repeatable detection, and the high-definition probe is able to show tiny lesions, echogenicity, blood flow signal, and other characteristics of foci. Combining color Doppler ultrasonography with testing thyroid autoantibodies such as TgAb, TPOAb, and TRAb can effectively improve the detection rate of early thyroid cancer, presenting significant reference value and meaning to clinical diagnosis and treatment of thyroid cancer.
目的
探讨彩色多普勒超声联合甲状腺自身抗体检测在甲状腺癌早期诊断中的应用价值。
方法
回顾性分析 2019 年 6 月至 2021 年 6 月我院收治的 100 例甲状腺结节患者的医学资料；所有患者术前均接受彩色多普勒超声和甲状腺自身抗体检查，并根据术后病理结果（金标准）分为良性病变组（n=45）和恶性病变组（n=55），比较分析彩色多普勒超声、甲状腺自身抗体检查及其联合检查在甲状腺癌早期诊断中的应用价值。
结果
与病理结果比较，联合诊断的准确率、灵敏度、特异度、阳性预测值、阴性预测值均明显高于彩色多普勒超声、TgAb 检测、TPOAb 检测、TRAb 检测单项诊断（P<0.05），并通过绘制 ROC 曲线分析这些方法诊断早期甲状腺疾病的效果，结果显示曲线下面积由大到小依次为联合诊断、彩色多普勒超声、TgAb 检测、TPOAb 检测、TRAb 检测。
结论
彩色多普勒超声在诊断甲状腺结节方面具有操作简便、无痛、无创、高效、可重复检测等诸多优点，高清探头能够显示病灶的微小病变、回声性、血流信号等特征。将彩色多普勒超声与 TgAb、TPOAb、TRAb 等甲状腺自身抗体检测相结合，能有效提高早期甲状腺癌的检出率，对临床甲状腺癌的诊断和治疗具有重要的参考价值和意义。
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