复方中药油减轻瑞戈非尼所致手足皮肤反应的疗效
Efficacy of compound traditional Chinese medicine oil in alleviating regorafenib-induced hand-foot skin reaction.
作者信息
Zhang Liyan, Cai Jieyuan, Sun Hong, Shen Lin
机构信息
The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
Department of Integrative Medicine & Geriatric Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
出版信息
Asia Pac J Oncol Nurs. 2021 Dec 25;9(2):125-129. doi: 10.1016/j.apjon.2021.10.002. eCollection 2022 Feb.
OBJECTIVE
Regofinib is a novel, oral, anticancer target which greatly improves survival of patients with colorectal cancer. However, it causes 47%-71% patients occur hand-foot skin reaction (HFSR), which affects the quality of life (QOL) or prognosis of patients. However targeted and effective methods are rare. The study attempted to test the efficacy of the compound traditional Chinese medicine (CTCM) oil in relieving HFSR and improving the QOL.
METHODS
The present study was conducted in 85 patients with metastatic colorectal cancer presenting with HFSR from July 2019 to June 2020. These patients were divided into the control group ( = 42) and the intervention group ( = 43). The HFSR in the control group was managed using traditional methods, whereas that in the intervention group was treated with a CTCM oil comprising five selected herbs. This oil functions by regulating the vascular endothelial growth factor receptor, inflammatory factors, and immune status, and it was provided to the patients to apply externally twice a day. HFSR remission and QOL were evaluated in both groups after 2 weeks of intervention.
RESULTS
The post-intervention HFSR remission rate was significantly higher in the intervention group than in the control group (65.1% vs. 16.7%) ( < 0.01). The overall QOL, physical function, social function, and emotional function of the patients in the intervention group were significantly improved ( < 0.05), whereas the pain symptoms were more significantly improved ( < 0.01).
CONCLUSIONS
The CTCM oil can effectively alleviate HFSR and improve the QOL of patients using regorafenib.
目的
瑞戈非尼是一种新型口服抗癌靶向药物，可显著提高结直肠癌患者的生存率。然而，它会导致47%-71%的患者出现手足皮肤反应（HFSR），这会影响患者的生活质量（QOL）或预后。然而，针对性强且有效的方法却很少见。本研究试图测试中药复方（CTCM）油在缓解HFSR和改善QOL方面的疗效。
方法
本研究于2019年7月至2020年6月对85例出现HFSR的转移性结直肠癌患者进行。这些患者被分为对照组（=42）和干预组（=43）。对照组的HFSR采用传统方法处理，而干预组则用一种由五种选定草药组成的CTCM油进行治疗。这种油通过调节血管内皮生长因子受体、炎症因子和免疫状态发挥作用，并提供给患者每天外用两次。干预2周后对两组的HFSR缓解情况和QOL进行评估。
结果
干预组干预后的HFSR缓解率显著高于对照组（65.1%对16.7%）（<0.01）。干预组患者的总体QOL、身体功能、社会功能和情感功能均显著改善（<0.05），而疼痛症状改善更为显著（<0.01）。
结论
CTCM油可有效缓解使用瑞戈非尼患者的HFSR并改善其QOL。
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