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外用中药联合尿素软膏治疗瑞戈非尼引起的手足皮肤反应：1例报告及文献复习

Management of Regorafenib-Induced Hand-Foot Skin Reaction with Topical Chinese Medicine and Urea Ointment: A Case Report and Literature Review.

作者信息

Liu Zhe-Ning, Shen Yu-Lei, Dong Hui-Jing, Tan Ke-Xin, Li Jia, Peng Yan-Mei, Cui Hui-Juan

机构信息

Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Oncology Department of Integrative Medicine, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China.

出版信息

Onco Targets Ther. 2025 Apr 9;18:509-519. doi: 10.2147/OTT.S510766. eCollection 2025.

DOI:10.2147/OTT.S510766
PMID:40225901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11994073/
Abstract

Regorafenib, a multikinase inhibitor, frequently induces severe hand-foot skin reactions (HFSR), often requiring dose reduction or discontinuation. This case report demonstrates the successful management of HFSR in a patient with fibromyxoid sarcoma using topical Chinese medicine "Shouzuping" soaking combined with urea ointment. It suggests the unique advantages of integrated traditional Chinese and Western medicine in managing HFSR. This article further reviews the clinical characteristics, pathogenesis, prevention and treatment strategies of HFSR caused by targeted therapies, with a view to providing valuable clinical insights.

摘要

瑞戈非尼是一种多激酶抑制剂，常引发严重的手足皮肤反应（HFSR），常需减量或停药。本病例报告展示了使用中药“手足平”浸泡联合尿素软膏成功治疗一名纤维黏液样肉瘤患者的HFSR。这表明中西医结合在治疗HFSR方面具有独特优势。本文进一步综述了靶向治疗引起的HFSR的临床特征、发病机制、预防和治疗策略，以期提供有价值的临床见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/660e6900fc22/OTT-18-509-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/1723d079e341/OTT-18-509-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/50b8a05b3275/OTT-18-509-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/0a7e1cecd907/OTT-18-509-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/27c7cbae2c08/OTT-18-509-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/660e6900fc22/OTT-18-509-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/1723d079e341/OTT-18-509-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/50b8a05b3275/OTT-18-509-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/0a7e1cecd907/OTT-18-509-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/27c7cbae2c08/OTT-18-509-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0995/11994073/660e6900fc22/OTT-18-509-g0005.jpg

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本文引用的文献

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Biology and Management of High-Grade Myxofibrosarcoma: State of the Art and Future Perspectives.高级别黏液纤维肉瘤的生物学特性与管理：现状与未来展望
Diagnostics (Basel). 2023 Sep 22;13(19):3022. doi: 10.3390/diagnostics13193022.
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Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems.绿原酸：抗炎机制、疾病治疗及相关递送系统综述
Front Pharmacol. 2023 Sep 13;14:1218015. doi: 10.3389/fphar.2023.1218015. eCollection 2023.
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Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes.
丹酚酸B：药理作用、安全性、联合治疗、新剂型及新型给药途径综述
Pharmaceutics. 2023 Aug 29;15(9):2235. doi: 10.3390/pharmaceutics15092235.
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The Efficacy and Safety of the Shouzu Ning Decoction Treatment Versus Halometasone Plus Celecoxib Treatment in Patients With Grade 2 HFSR: A Randomized Clinical Trial.芍药宁方治疗 2 级手足综合征与卤米松联合塞来昔布治疗的疗效和安全性：一项随机临床试验。
Integr Cancer Ther. 2023 Jan-Dec;22:15347354231168796. doi: 10.1177/15347354231168796.
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augments endothelial cell function for ischemic hindlimb recovery.增强内皮细胞功能，促进缺血性后肢恢复。
Biol Chem. 2023 Mar 6;405(2):119-128. doi: 10.1515/hsz-2022-0316. Print 2024 Feb 26.
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Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice.反复局部应用芍药苷可减轻小鼠术后疼痛并加速皮肤成纤维细胞增殖。
J Pharmacol Sci. 2023 Feb;151(2):84-87. doi: 10.1016/j.jphs.2022.12.004. Epub 2022 Dec 19.
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Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage.黄芩对银屑病样病变的治疗作用：通过调节角质形成细胞和巨噬细胞的反应。
Biomed Pharmacother. 2022 Nov;155:113798. doi: 10.1016/j.biopha.2022.113798. Epub 2022 Oct 4.
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Regorafenib for the Treatment of Sarcoma.瑞戈非尼治疗肉瘤。
Curr Treat Options Oncol. 2022 Nov;23(11):1477-1502. doi: 10.1007/s11864-022-00990-0. Epub 2022 Sep 30.
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