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右半肝活体肝移植术后吻合口胆道并发症初始治疗的最佳干预措施。

Optimal Intervention for Initial Treatment of Anastomotic Biliary Complications After Right Lobe Living Donor Liver Transplantation.

机构信息

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

出版信息

Transpl Int. 2022 Apr 22;35:10044. doi: 10.3389/ti.2022.10044. eCollection 2022.

Abstract

This study evaluated endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) as interventions for patients with anastomotic biliary complications (ABC) after living donor liver transplantation (LDLT). Prospectively collected data of patients who were diagnosed with ABC after LDLT between January 2013 and June 2017 were retrospectively reviewed. There were 57 patients who underwent LDLT with a right liver graft using duct-to-duct biliary reconstruction and experienced ABC. Among the patients with RAD involvement, there were no significant differences in the intervention success ( = 0.271) and patency rates ( = 0.267) between ERCP and PTBD. Similarly, among the patients with RPD involvement, there were no significant differences in the intervention success ( = 0.148) and patency rates ( = 0.754) between the two procedures. Graft bile duct variation ( = 0.013) and a large angle between the recipient and graft bile duct (R-G angle) ( = 0.012) significantly increased the likelihood of failure of ERCP in the RAD. When the R-G angle was greater than 47.5°, the likelihood of ERCP failure increased. We recommend PTBD when graft bile duct variation is presented in patients with RAD involvement and/or when the R-G angle is greater than 47.5°.

摘要

本研究评估了内镜逆行胰胆管造影术(ERCP)和经皮经肝胆管引流术(PTBD)作为活体肝移植(LDLT)后吻合口胆道并发症(ABC)患者的介入治疗方法。回顾性分析了 2013 年 1 月至 2017 年 6 月期间因 LDLT 后发生 ABC 而被诊断为 ABC 的患者的前瞻性收集数据。57 例采用右肝外胆管端端吻合术行 LDLT 患者发生 ABC。在 RAD 受累患者中,ERCP 和 PTBD 的介入成功率(=0.271)和通畅率(=0.267)无显著差异。同样,在 RPD 受累患者中,两种方法的介入成功率(=0.148)和通畅率(=0.754)无显著差异。胆管变异(=0.013)和受体胆管与供体胆管之间的夹角(R-G 角)(=0.012)显著增加了 RAD 中 ERCP 失败的可能性。当 R-G 角大于 47.5°时,ERCP 失败的可能性增加。我们建议在 RAD 受累患者中出现胆管变异和/或 R-G 角大于 47.5°时选择 PTBD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debc/9073559/e6ec91bebfef/ti-35-10044-g001.jpg

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