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活体肝移植术后胆系并发症的处理

Management of biliary complications after LDLT.

作者信息

Bhangui Prashant

机构信息

Master in HPB Surgery (Henri Bismuth Hepatobiliary Institute, France), European Inter-University Diploma in HPB Oncology, Fellowship in Hepatobiliary Surgery and Liver Transplantation (Hopital Paul Brousse, France), Director, Liver Transplantation and Hepatobiliary Surgery, Medanta Institute Of Liver Transplantation and Regenerative Medicine, Medanta - The Medicity, Gurgaon, Delhi NCR, 122001, India.

出版信息

Updates Surg. 2024 Sep 14. doi: 10.1007/s13304-024-01988-z.

Abstract

Biliary complications (BC) in the recipient continue to be an as yet, unresolved issue following living donor liver transplantation (LDLT). Bile leaks (BL) and biliary anastomotic strictures (BAS) are the most common BCs, with the latter contributing to close to 80%. With increasing expertise, endoscopic treatment with endoscopic retrograde cholangiography (ERC) [the first-line treatment] and percutaneous transhepatic cholangiography (PTC) with percutaneous transhepatic biliary drainage (PTBD) alone or in combination with ERC lead to successful management in a majority of these cases. However, prediction of difficulty of endoscopic success in biliary strictures, optimal duration of indwelling stents and their planned removal, management options in high-grade strictures (HGS) and the long-term outcome of patients requiring intervention for BC's are still unanswered questions in this setting. This review will try to summarise pertinent issues, novel insights and finally propose basic principles to be adhered to when dealing with the gamut of possible biliary complications after LDLT.

摘要

在活体肝移植(LDLT)后,受者的胆道并发症(BC)仍然是一个尚未解决的问题。胆漏(BL)和胆道吻合口狭窄(BAS)是最常见的BC,后者占近80%。随着专业技术的提高,通过内镜逆行胆管造影(ERC)进行内镜治疗[一线治疗]以及单独或联合ERC进行经皮肝穿刺胆管造影(PTC)和经皮肝穿刺胆道引流(PTBD),在大多数此类病例中都能成功处理。然而,胆道狭窄内镜治疗成功难度的预测、留置支架的最佳持续时间及其计划取出、高级别狭窄(HGS)的处理选择以及需要对BC进行干预的患者的长期结局,在这种情况下仍然是未解决的问题。本综述将试图总结相关问题、新见解,并最终提出在处理LDLT后可能出现的各种胆道并发症时应遵循的基本原则。

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