用于分次光卟啉介导光动力疗法（PDT）的活性氧明确剂量测定法（ROSED）
Reactive oxygen species explicit dosimetry (ROSED) for fractionated photofrin-mediated photodynamic therapy (PDT).
作者信息
Sun Hongjing, Ong Yi Hong, Zhu Timothy C
机构信息
Department of Radiation Oncology, Perelman Center for Advanced Medicine (PCAM), University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb;11940. doi: 10.1117/12.2609969. Epub 2022 Mar 4.
Abstract
Photodynamic therapy (PDT) is an established modality for cancer treatment and reactive oxygen species explicit dosimetry (ROSED), based on direct measurements of in-vivo light fluence (rate), in-vivo photofrin concentration, and tissue oxygenation concentration, has been proved to be an effective dosimetric quantity which can be used to predict PDT outcome. In this study, ROSED was performed for photofrin-mediated PDT for mice bearing radiation-induced fibrosacorma (RIF) tumor. PDT treatments were performed using single or fractionated illumination to a same total fluence of 135 Jcm. The effects of light fractionation on the total reacted [ROS] and treatment outcomes were evaluated.
摘要
光动力疗法（PDT）是一种既定的癌症治疗方式，而基于对体内光通量（率）、体内卟啉浓度和组织氧合浓度的直接测量的活性氧物种显式剂量测定法（ROSED），已被证明是一种可用于预测PDT疗效的有效剂量测定量。在本研究中，对携带辐射诱导纤维肉瘤（RIF）肿瘤的小鼠进行了卟啉介导的PDT的ROSED。使用单次或分次照射，总通量均为135 J/cm²来进行PDT治疗。评估了光分次照射对总反应性[ROS]和治疗效果的影响。
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