Mendiratta Gaurav, Jones Michael K, Stites Edward C
Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Mol Cell Oncol. 2022 May 1;9(1):2065176. doi: 10.1080/23723556.2022.2065176. eCollection 2022.
Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes are most commonly mutated, pan-cancer? have only been recently answered. Here, we highlight this recent advance.
来自癌症患者的基因组测序样本有助于确定不同突变类型的作用，并推动靶向治疗的发展。然而，诸如患者中的基因突变率是多少？或者在泛癌中最常发生突变的基因是什么？等关键问题直到最近才得到解答。在此，我们重点介绍这一最新进展。
