可交联双嵌段三元共聚物PDPA-P(NMS-OEG)的合成及壳交联pH/氧化还原双响应胶束作为智能纳米材料的制备。

Synthesis of crosslinkable diblock terpolymers PDPA--P(NMS--OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials.

作者信息

Sun Jingjing, Wang Zhao, Cao Amin, Sheng Ruilong

机构信息

Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072 China.

Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, CAS Lingling Road 345 Shanghai 200032 China.

出版信息

RSC Adv. 2019 Oct 29;9(59):34535-34546. doi: 10.1039/c9ra05082e. eCollection 2019 Oct 23.

Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA--P(NMS--OEG) diblock terpolymers (P1-P3) were designed and prepared RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles cystamine-based shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential "smart" nanocarriers for drug delivery.

交联聚合物纳米材料因其稳定性和高度可控的药物递送而备受关注；在此，通过可逆加成-断裂链转移（RAFT）聚合设计并制备了一系列结构明确的两亲性聚（2-二甲基氨基乙基丙烯酸酯）-聚（N-甲基丙烯酰氧琥珀酰亚胺-聚乙二醇）三嵌段共聚物（P1-P3），它们自组装成非交联（NCL）纳米胶束，进一步通过基于胱胺的壳交联制备成壳交联（SCL）胶束。以P3作为优化聚合物，制备了SCL-P3胶束，其表现出显著的pH/氧化还原双响应行为。用于药物递送时，制备了载有喜树碱（CPT）的SCL-P3胶束，其CPT负载能力比NCL-P3对应物高得多。值得注意的是，SCL-P3胶束表现出良好的pH/氧化还原双响应协同CPT释放特性，使其成为潜在的药物递送“智能”纳米载体。