Niu Xiaoqin, Li Dan, Chen Yuhong, Ran Fen
College of Petrochemical Technology, Lanzhou University of Technology Lanzhou 730050 P. R. China
School of Material Science and Engineering, Lanzhou University of Technology Lanzhou 730050 Gansu P. R. China.
RSC Adv. 2019 Aug 13;9(44):25274-25284. doi: 10.1039/c9ra04234b.
Polyethersulfone (PES) has good thermal stability, superior pH, chlorine tolerance, and excellent chemical resistance; however, the hydrophilicity and biocompatibility of PES need to be improved for its real applications. In this study, we report a surface modification method for the preparation of a functional PES membrane with hydrophilic polymer chains (MPC and GMA) surface-initiated electrochemically-mediated atom-transfer radical polymerization (SI-ATRP) technology, and the Arg-Glu-Asp-Val polypeptide groups (REDV) were immobilized onto the modified membrane by a ring-opening reaction. XPS and SEM were used to analyze the chemical composition and morphology of the modified membrane surfaces, confirming that the hydrophilic polymer chains MPC and GMA and the polypeptide group REDV were successfully grafted onto the PES membrane surface. The static water contact angle decreased from 89° to 50-65°, and the hydrophilic property of the modified membrane was enhanced. The water flux increased from 4.29 L m h for the pristine PES membrane to 25 L m h for the modified membrane with PGMA chains grafted on it and REDV functional groups immobilized on it; note that the antifouling tests showed that all the modified membranes had the higher flux recovery ratio values (FRR) of above 80% than the pristine PES membrane (about 60%), and the APTT for the modified membrane increased from 46 s to 93 s, indicating that these modified membranes could be applied in the separation and blood purification fields.
聚醚砜（PES）具有良好的热稳定性、优异的pH耐受性、耐氯性和出色的耐化学性；然而，为了其实际应用，PES的亲水性和生物相容性需要得到改善。在本研究中，我们报道了一种表面改性方法，通过表面引发电化学介导的原子转移自由基聚合（SI-ATRP）技术制备具有亲水性聚合物链（MPC和GMA）的功能性PES膜，并通过开环反应将精氨酸-谷氨酸-天冬氨酸-缬氨酸多肽基团（REDV）固定在改性膜上。采用X射线光电子能谱（XPS）和扫描电子显微镜（SEM）分析改性膜表面的化学成分和形态，证实亲水性聚合物链MPC和GMA以及多肽基团REDV成功接枝到PES膜表面。静态水接触角从89°降至50 - 65°，改性膜的亲水性得到增强。水通量从原始PES膜的4.29 L m⁻² h⁻¹增加到接枝有PGMA链并固定有REDV官能团的改性膜的25 L m⁻² h⁻¹；注意，抗污染测试表明，所有改性膜的通量恢复率（FRR）值均高于原始PES膜（约60%），达到80%以上，并且改性膜的活化部分凝血活酶时间（APTT）从46 s增加到93 s，表明这些改性膜可应用于分离和血液净化领域。
