在空气中通过小体积电子转移活化再生催化剂原子转移自由基聚合制备结构明确的聚合物和DNA-聚合物生物共轭物。
Preparation of Well-Defined Polymers and DNA-Polymer Bioconjugates via Small-Volume eATRP in the Presence of Air.
作者信息
Sun Yue, Lathwal Sushil, Wang Yi, Fu Liye, Olszewski Mateusz, Fantin Marco, Enciso Alan E, Szczepaniak Grzegorz, Das Subha, Matyjaszewski Krzysztof
机构信息
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States.
出版信息
ACS Macro Lett. 2019 May 21;8(5):603-609. doi: 10.1021/acsmacrolett.9b00159. Epub 2019 May 6.
An aqueous electrochemically mediated atom transfer radical polymerization (eATRP) was performed in a small volume solution (75 μL) deposited on a screen-printed electrode (SPE). The reaction was open to air, thanks to the use of glucose oxidase (GOx) as an oxygen scavenger. Well-defined poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), poly(oligo(ethylene oxide) methyl ether methacrylate) (POEOMA), and corresponding DNA-polymer biohybrids were synthesized by the small-volume eATRP at room temperature. The reactions were simplified and polymerization rates increased by the application of the enzyme deoxygenating system and the compact electrochemical setup. Importantly, the volume of polymerization mixture was lowered to microliters, which not only decreases the cost for each reaction, but can also be potentially implemented in combinatorial chemistry and electrode-array configurations for high-throughput systems.
在沉积于丝网印刷电极（SPE）上的小体积溶液（75 μL）中进行了水相电化学介导的原子转移自由基聚合反应（eATRP）。由于使用葡萄糖氧化酶（GOx）作为氧清除剂，该反应可在空气中进行。通过小体积eATRP在室温下合成了结构明确的聚（2-（甲基亚磺酰基）乙基丙烯酸酯）（PMSEA）、聚（聚（环氧乙烷）甲基醚甲基丙烯酸酯）（POEOMA）以及相应的DNA-聚合物生物杂化物。酶脱氧系统和紧凑的电化学装置简化了反应并提高了聚合速率。重要的是，聚合混合物的体积降至微升，这不仅降低了每个反应的成本，还可潜在地应用于组合化学和高通量系统的电极阵列配置中。
Zotero 插件