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磷化铁纳米颗粒作为用于磁共振肿瘤成像的pH响应性造影剂。

Iron phosphide nanoparticles as a pH-responsive contrast agent for magnetic resonance tumor imaging.

作者信息

Qiu Yuan, Lin Weiwen, Wang Lili, Liu Rui, Xie Jiangao, Chen Xin, Yang Feifei, Huang Guoming, Yang Huanghao

机构信息

College of Biological Science and Engineering, Fuzhou University Fuzhou 350116 P. R. China

Department of Diagnostic Radiology, Union Hospital, Fujian Medical University Fuzhou 350001 P. R. China.

出版信息

RSC Adv. 2019 Sep 26;9(52):30581-30584. doi: 10.1039/c9ra06886d. eCollection 2019 Sep 23.

DOI:10.1039/c9ra06886d
PMID:35530245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072189/
Abstract

In this work, the potential of FeP nanoparticles as a pH-responsive contrast agent was investigated. The FeP nanoparticles have good biocompatibility and can significantly amplify magnetic resonance signals in response to the acidic microenvironment of solid tumors, holding great promise in serving as an acid-activatable contrast agent for tumor imaging.

摘要

在这项工作中，研究了FeP纳米颗粒作为pH响应性造影剂的潜力。FeP纳米颗粒具有良好的生物相容性，并且能够响应实体瘤的酸性微环境而显著放大磁共振信号，在用作肿瘤成像的酸激活造影剂方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/7a34c8a11af1/c9ra06886d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/5f5188b90d3b/c9ra06886d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/3c42fe98ef1f/c9ra06886d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/a01a231bfd1e/c9ra06886d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/7a34c8a11af1/c9ra06886d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/5f5188b90d3b/c9ra06886d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/3c42fe98ef1f/c9ra06886d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/a01a231bfd1e/c9ra06886d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa1e/9072189/7a34c8a11af1/c9ra06886d-f4.jpg

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