Polman C H, Dijkstra C D, de Groot C J, Koetsier J C, Sminia T
Int Arch Allergy Appl Immunol. 1987;83(1):109-11. doi: 10.1159/000234340.
The rat central nervous system (CNS) was analyzed immunohistochemically during various pathological conditions by using monoclonal antibodies specific for rat T lymphocytes, rat macrophages and Ia antigen. It was found that in immunologically mediated disease infiltrating macrophages do express the Ia antigen, whereas in nonimmunologically mediated disease they do not. The results suggest that based on the composition of the mononuclear phagocyte infiltrate a clear distinction can be made between different inflammatory reaction types within the CNS.
利用针对大鼠T淋巴细胞、大鼠巨噬细胞和Ia抗原的单克隆抗体，对处于各种病理状态下的大鼠中枢神经系统（CNS）进行了免疫组织化学分析。结果发现，在免疫介导的疾病中，浸润的巨噬细胞确实表达Ia抗原，而在非免疫介导的疾病中则不表达。这些结果表明，根据单核吞噬细胞浸润的组成，可以在中枢神经系统内的不同炎症反应类型之间做出明确区分。
