Ramirez G, Butcher D E, Morrison A D
Int J Artif Organs. 1987 Jan;10(1):31-6.
In order to assess the effect of varying glucose concentrations on plasma lipids, we first compared the hormonal response of nine non-diabetic patients during dialysis with a high (200 mg/dl) and a low (100 mg/dl) glucose bath. Insulin and growth hormone production increased (p less than 0.05) only with the high glucose bath, and no hemodynamic differences were noted during either dialyses. We then compared lipid profiles of 18 patients for 6 months, changing the glucose dialysate concentrations in each patient after three months. We found that all patients had hypertriglyceridemia, mild hypercholesterolemia, low HDL, normal LDL, and high VLDL cholesterol. We therefore conclude that episodic hyperinsulinemia and episodic excessive growth hormone secretion do not contribute significantly to the lipid abnormalities of the dialysis patients.
为了评估不同葡萄糖浓度对血脂的影响，我们首先比较了9名非糖尿病患者在透析期间，使用高葡萄糖浓度（200mg/dl）透析液和低葡萄糖浓度（100mg/dl）透析液时的激素反应。仅在使用高葡萄糖浓度透析液时，胰岛素和生长激素分泌增加（p<0.05），且两种透析期间均未观察到血流动力学差异。然后，我们比较了18名患者6个月的血脂谱，每位患者在3个月后更换葡萄糖透析液浓度。我们发现所有患者均有高甘油三酯血症、轻度高胆固醇血症、低高密度脂蛋白、正常低密度脂蛋白以及高极低密度脂蛋白胆固醇。因此，我们得出结论，间歇性高胰岛素血症和间歇性生长激素过度分泌对透析患者的脂质异常没有显著影响。
