Eswarappa Mahesh, Suryadevara Saritha, R Rajashekar, K B Mahesh Kumar, K C Gurudev, Tyagi Puru, V Avin
Nephrology, Ramaiah Medical College, Bangalore, IND.
Nephrology, Amsa Renal Care, Mount Fleuri, SYC.
Cureus. 2022 Apr 6;14(4):e23899. doi: 10.7759/cureus.23899. eCollection 2022 Apr.
Diabetic kidney disease (DKD) is the commonest cause of chronic kidney disease and end-stage kidney disease worldwide, consequently it has become an important productive implication to the healthcare system. This study was conducted to assess the prevalence of non-DKD (NDKD) in diabetic patients from south India.
To assess the prevalence of NDKD in type 2 diabetes mellitus patients presenting to a tertiary care hospital from south India and also to analyze clinical clues to establish a diagnosis of NDKD.
It is a retrospective observational study of analyzing patient characteristics and renal biopsies. All Diabetic patients with a clinical suspicion of non-diabetic kidney disease who underwent renal biopsy during the study period between January 2012 and June 2017 were included. Based on the biopsy findings, the patients were classified into three groups (isolated diabetic nephropathy, isolated NDKD, and NDKD with underlying diabetic nephropathy) and patients' characteristics were compared between the groups for analysis.
A total of 236 renal biopsies were analyzed for the study. Of that, 114 had features of DKD, 78 NDKD with diabetic nephropathy (DN) and 44 had isolated NDKD. Acute interstitial nephritis was the most common cause of NDKD.
From the current study, the long duration of diabetes mellitus beyond five years and hypertension beyond two years reasonably predict DKD.
糖尿病肾病（DKD）是全球慢性肾病和终末期肾病最常见的病因，因此已成为医疗保健系统的一项重要经济负担。本研究旨在评估印度南部糖尿病患者中非糖尿病肾病（NDKD）的患病率。
评估来自印度南部一家三级护理医院的2型糖尿病患者中NDKD的患病率，并分析用于确诊NDKD的临床线索。
这是一项分析患者特征和肾活检的回顾性观察研究。纳入了2012年1月至2017年6月研究期间所有临床怀疑患有非糖尿病肾病且接受了肾活检的糖尿病患者。根据活检结果，将患者分为三组（孤立性糖尿病肾病、孤立性NDKD以及合并潜在糖尿病肾病的NDKD），并对组间患者特征进行比较分析。
本研究共分析了236例肾活检病例。其中，114例具有DKD特征，78例为合并糖尿病肾病（DN）的NDKD，44例为孤立性NDKD。急性间质性肾炎是NDKD最常见的病因。
从当前研究来看，糖尿病病程超过五年且高血压病程超过两年可合理预测DKD。
