Pd/C催化剂上苯乙腈的氢化反应：迈向机理理解
The hydrogenation of mandelonitrile over a Pd/C catalyst: towards a mechanistic understanding.
作者信息
McAllister Mairi I, Boulho Cédric, McMillan Liam, Gilpin Lauren F, Brennan Colin, Lennon David
机构信息
School of Chemistry, University of Glasgow Joseph Black Building Glasgow G12 8QQ UK
Syngenta, Jeallot's Hill International Research Centre Bracknell Berkshire RG42 6EY UK.
出版信息
RSC Adv. 2019 Aug 21;9(45):26116-26125. doi: 10.1039/c9ra04618f. eCollection 2019 Aug 19.
A carbon supported Pd catalyst is used in the liquid phase hydrogenation of the aromatic cyanohydrin mandelonitrile (CHCH(OH)CHCN) to afford the primary amine phenethylamine (CHCHCHNH). Employing a batch reactor, the desired primary amine is produced in 87% selectivity at reaction completion. Detection of the by-product 2-amino-1-phenylethanol (CHCH(OH)CHNH) accounts for the remaining 13% and closes the mass balance. The reaction mechanism is investigated, with a role for both hydrogenation and hydrogenolysis processes established.
一种碳负载的钯催化剂用于芳香族氰醇苯乙腈（CHCH(OH)CHCN）的液相加氢反应，以生成伯胺苯乙胺（CHCHCHNH）。采用间歇式反应器，在反应完成时以87%的选择性生成所需的伯胺。副产物2-氨基-1-苯乙醇（CHCH(OH)CHNH）的检测占剩余的13%，从而实现了质量平衡。对反应机理进行了研究，确定了氢化和氢解过程均起作用。
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