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肾移植受者感染的尿路感染-流行病学、毒力和抗生素耐药性。

Urinary Tract Infections Caused by in Kidney Transplant Recipients - Epidemiology, Virulence and Antibiotic Resistance.

机构信息

Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.

Medical Center MML, Warsaw, Poland.

出版信息

Front Cell Infect Microbiol. 2022 Apr 21;12:861374. doi: 10.3389/fcimb.2022.861374. eCollection 2022.

Abstract

Urinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient's death. has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk factors associated with urinary tract infections in kidney transplant recipients, multi-drug resistance of (ESBL, KPC, NDM), treatment and pathogenesis of infections, and possible causes of recurrent UTIs. It also addresses the issue of colonization/becoming a carrier of in the gastrointestinal tract and asymptomatic bacteriuria in relation to a symptomatic UTI development and epidemiology.

摘要

尿路感染是肾移植受者最常见的并发症,可能导致长期肾移植物功能恶化和受者死亡风险增加。在复发性尿路感染的情况下,尤其是在耐多药菌株的情况下,已经成为最常见的病原体之一。本文讨论了肾移植受者尿路感染的流行病学和危险因素、(ESBL、KPC、NDM)的多药耐药性、感染的治疗和发病机制,以及复发性 UTIs 的可能原因。它还涉及与症状性 UTI 发展和流行病学相关的胃肠道定植/成为的问题和无症状菌尿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5217/9068989/b427756f37f8/fcimb-12-861374-g001.jpg

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