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病例报告:一名二次肾移植患者的多重耐药感染病例管理

Case Report: Management of a case of multidrug-resistant infection in a second-kidney transplant patient.

作者信息

Shettar Supreeta R, Sumana Mahadevaiah Neelambike, Shetty Manjunath S, Maheshwarappa Yogeesh D, Raghukanth Reddy G, Srinivasan Asha, Vamshi Dharan P, Kalyatanda Gautam, Veerabhadra Swamy G S, Chinchana Shylaja Eshwarappa

机构信息

JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India.

Department of Nanoscience and Technology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, India.

出版信息

Front Transplant. 2025 Jan 17;3:1494016. doi: 10.3389/frtra.2024.1494016. eCollection 2024.

Abstract

This case report on recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) in a post-renal transplant patient underscores the significant clinical challenge of managing MDR infections in immunocompromised individuals, particularly in the context of renal transplantation. The patient was treated with an extended infusion of meropenem, which offers prolonged drug exposure and enhances bactericidal activity against MDR pathogens. This approach is critical in overcoming the resistance mechanisms inherent to , thereby improving the likelihood of therapeutic success. The findings presented here highlight the potential efficacy of extended meropenem infusion in treating MDR infections, providing a valuable therapeutic option for clinicians facing similar cases. This report contributes to the growing evidence supporting advanced antibiotic administration techniques in managing complicated urinary tract infections in transplant in resource limited countries.

摘要

本病例报告讲述了一名肾移植术后患者发生的由多重耐药菌引起的复发性尿路感染,突显了在免疫功能低下个体中,尤其是在肾移植背景下,应对多重耐药菌感染所面临的重大临床挑战。该患者接受了美罗培南延长输注治疗,这种方法可延长药物暴露时间,并增强对多重耐药病原体的杀菌活性。这种方法对于克服多重耐药菌固有的耐药机制至关重要,从而提高治疗成功的可能性。此处呈现的研究结果突出了美罗培南延长输注在治疗多重耐药菌感染方面的潜在疗效,为面临类似病例的临床医生提供了一种有价值的治疗选择。本报告为支持在资源有限国家的移植患者中管理复杂尿路感染时采用先进抗生素给药技术的越来越多的证据做出了贡献。

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