Bahari Hossein, Tajik Ali, Doostparast Armin, Abadi Reza Nejad Shahrokh, Javanshir Saeed, Aliakbarian Mohsen, Khodashahi Rozita
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Clin Transplant Res. 2025 Jun 30;39(2):116-123. doi: 10.4285/ctr.24.0070. Epub 2025 Mar 14.
Recurrent urinary tract infections (UTIs) are a common complication among renal transplant recipients and can significantly affect patient outcomes. This study investigates the antibiogram patterns of uropathogens in this population to improve treatment strategies.
We performed a retrospective analysis of 58 renal transplant recipients diagnosed with recurrent UTIs. Pathogen types and antibiotic sensitivity profiles were documented using VITEK2 (bioMérieux). Inclusion criteria required that patients had undergone renal transplantation within the previous 5 years, experienced at least one confirmed UTI episode, and had complete antibiogram profiles. Only bacterial infections confirmed by both positive cultures and symptoms were included; cases with negative cultures or asymptomatic bacteriuria were excluded.
was the predominant pathogen (58%), followed by spp. (16%) and (10%). Notably, high resistance rates were observed against commonly used antibiotics; for example, exhibited 100% resistance to ampicillin and cefazolin. Statistical analysis revealed significant differences in resistance patterns among the various microorganisms, highlighting the prevalence of multidrug-resistant strains.
The findings highlight the urgent need for continuous monitoring of antibiogram patterns and the development of disease-specific antibiograms tailored to renal transplant recipients to optimize treatment strategies and improve patient outcomes. The high prevalence of antibiotic resistance indicates that empirical antibiotic guidelines must be revised to ensure effective management of UTIs in this vulnerable population.
复发性尿路感染（UTIs）是肾移植受者常见的并发症，可显著影响患者预后。本研究调查该人群尿路病原体的抗菌谱模式，以改进治疗策略。
我们对58例诊断为复发性UTIs的肾移植受者进行了回顾性分析。使用VITEK2（生物梅里埃公司）记录病原体类型和抗生素敏感性谱。纳入标准要求患者在过去5年内接受了肾移植，经历过至少一次确诊的UTI发作，并且有完整的抗菌谱。仅纳入经阳性培养和症状证实的细菌感染；排除培养阴性或无症状菌尿的病例。
是主要病原体（58%），其次是 菌属（16%）和 菌（10%）。值得注意的是，观察到对常用抗生素的高耐药率；例如， 对氨苄西林和头孢唑林表现出100%的耐药性。统计分析显示不同微生物之间的耐药模式存在显著差异，突出了多重耐药菌株的普遍性。
研究结果强调迫切需要持续监测抗菌谱模式，并制定针对肾移植受者的疾病特异性抗菌谱，以优化治疗策略并改善患者预后。抗生素耐药性的高流行表明，必须修订经验性抗生素指南，以确保对这一脆弱人群的UTIs进行有效管理。
