Núñez-Villanueva Diego, Ciaccia Maria, Hunter Christopher A
Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK
RSC Adv. 2019 Sep 18;9(51):29566-29569. doi: 10.1039/c9ra07233k.
Covalent template-directed synthesis was used to oligomerise monomer building blocks in a controlled manner to give exclusively the linear trimer. Competing reaction pathways were blocked by addition of a large excess of a monomeric capping agent. At a concentration of 1 mM, the cap selectively prevented further reaction of the product chain ends to give polymeric and macrocyclic products, but did not interfere with the templating process.
共价模板导向合成法被用于以可控方式使单体结构单元低聚，从而仅生成线性三聚体。通过加入大量过量的单体封端剂来阻断竞争反应途径。在1毫摩尔的浓度下，封端剂选择性地阻止了产物链端的进一步反应，从而生成聚合物和大环产物，但不干扰模板过程。
