Seyedmirzaei Sarraf Seyedali, Rokhsar Talabazar Farzad, Namli Ilayda, Maleki Mohammadamin, Sheibani Aghdam Araz, Gharib Ghazaleh, Grishenkov Dmitry, Ghorbani Morteza, Koşar Ali
Faculty of Engineering and Natural Science, Sabanci University, 34956 Tuzla, Istanbul, Turkey.
Sabanci University Nanotechnology Research and Application Center, 34956 Tuzla, Istanbul, Turkey.
Lab Chip. 2022 Jun 14;22(12):2237-2258. doi: 10.1039/d2lc00169a.
Thanks to the developments in the area of microfluidics, the cavitation-on-a-chip concept enabled researchers to control and closely monitor the cavitation phenomenon in micro-scale. In contrast to conventional scale, where cavitation bubbles are hard to be steered and manipulated, lab-on-a-chip devices provide suitable platforms to conduct smart experiments and design reliable devices to carefully harness the collapse energy of cavitation bubbles in different bio-related and industrial applications. However, bubble behavior deviates to some extent when confined to micro-scale geometries in comparison to macro-scale. Therefore, fundamentals of micro-scale cavitation deserve in-depth investigations. In this review, first we discussed the physics and fundamentals of cavitation induced by tension-based as well as energy deposition-based methods within microfluidic devices and discussed the similarities and differences in micro and macro-scale cavitation. We then covered and discussed recent developments in bio-related applications of micro-scale cavitation chips. Lastly, current challenges and future research directions towards the implementation of micro-scale cavitation phenomenon to emerging applications are presented.
得益于微流控领域的发展，芯片上的空化概念使研究人员能够在微尺度上控制并密切监测空化现象。与传统尺度下空化气泡难以操控的情况不同，芯片实验室设备提供了合适的平台来开展智能实验，并设计可靠的装置，以便在不同的生物相关和工业应用中谨慎利用空化气泡的崩溃能量。然而，与宏观尺度相比，当气泡局限于微尺度几何结构时，其行为会在一定程度上发生偏差。因此，微尺度空化的基本原理值得深入研究。在这篇综述中，我们首先讨论了微流控装置中基于张力和基于能量沉积的方法所引发的空化的物理原理和基本情况，并探讨了微尺度和宏观尺度空化的异同。接着，我们涵盖并讨论了微尺度空化芯片在生物相关应用方面的最新进展。最后，介绍了将微尺度空化现象应用于新兴应用所面临的当前挑战和未来研究方向。
