Peking University People's Hospital, Beijing, China.
J Cosmet Dermatol. 2022 Nov;21(11):5804-5810. doi: 10.1111/jocd.15067. Epub 2022 May 29.
Scar brings great physical and mental pain to patients. Fat grafting may be a new and simple way to treat scar. This review aimed to systematically evaluate the correlation between fat grafting and scar reduction.
The author searched Chinese and English literature databases such as CNKI, Wanfang Data, Cqvip, Pubmed, Web of Science, Embase, CBM, etc. for articles published in the period from 2011 to 2021 about the randomized controlled trials (RCTs) to assess the effect of fat grating on scar reduction, and then performed meta-analysis with Review Manager 5.4.
A total of nine articles were included in the assessment of the effect of fat grafting on scar reduction, with meta-analysis suggesting statistical significance (OR = 5.63, 95% CI: 3.01-10.53, p < 0.01). There was statistical significance in the difference observed between the simple fat grating group (p = 0.004) and the group of existing therapies combined with fat grafting (p < 0.0001).
Fat grafting may be a good method for scar treatment, especially when it's combined with other therapies. Still, due to the limitations of included RCTs, more large-scale high-quality RCTs must be carried out before solid conclusions can be drawn.
瘢痕给患者带来了极大的身心痛苦。脂肪移植可能是一种治疗瘢痕的新方法。本综述旨在系统评估脂肪移植与瘢痕减少的相关性。
作者检索了中国知网、万方数据、维普、Pubmed、Web of Science、Embase、CBM 等中英文文献数据库，检索了 2011 年至 2021 年期间发表的关于评估脂肪移植对瘢痕减少效果的随机对照试验（RCT）的文章，并使用 Review Manager 5.4 进行荟萃分析。
共有 9 篇文章评估了脂肪移植对瘢痕减少的效果，荟萃分析显示具有统计学意义（OR=5.63，95%CI：3.01-10.53，p<0.01）。单纯脂肪移植组（p=0.004）与现有治疗方法联合脂肪移植组（p<0.0001）之间的差异具有统计学意义。
脂肪移植可能是治疗瘢痕的一种较好方法，尤其是与其他疗法联合使用时。然而，由于纳入的 RCT 存在局限性，必须开展更多大规模高质量的 RCT，才能得出确凿的结论。
