Miao Pandeng, Xi Ying, Feng Zijie, Zhang Jian, Du Yingxiang, Chen Cheng
Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, Jiangsu, P. R. China.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China.
Anal Methods. 2022 May 27;14(20):1982-1987. doi: 10.1039/d2ay00414c.
Nanoparticles, which have unique properties, have attracted growing attention in enantiomeric separation nowadays. In this paper, an L-cysteine functionalized gold nanoparticle (L-Cys-GNP) based capillary column was prepared and applied in separating drug enantiomers in capillary electrochromatography (CEC) with lactobionic acid (LA) as a chiral selector. Compared with bare fused-silica capillary columns, the capillary columns modified with L-Cys-GNPs showed excellent chiral separation performance. A series of parameters affecting the enantiomeric separation were systematically investigated.
具有独特性质的纳米颗粒如今在对映体分离中受到越来越多的关注。本文制备了一种基于L-半胱氨酸功能化金纳米颗粒（L-Cys-GNP）的毛细管柱，并将其应用于毛细管电色谱（CEC）中以乳糖酸（LA）作为手性选择剂分离药物对映体。与裸熔融石英毛细管柱相比，用L-Cys-GNPs修饰的毛细管柱表现出优异的手性分离性能。系统研究了一系列影响对映体分离的参数。
