Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382355, India E-mail: Dhiraj Bhatia.
Center for Biomedical Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382355, India.
Chem Rec. 2022 Aug;22(8):e202200048. doi: 10.1002/tcr.202200048. Epub 2022 May 9.
DNA is a polyanionic, hydrophilic, and natural biopolymer that offers properties such as biodegradability, biocompatibility, non-toxicity, and non-immunogenicity. These properties of DNA as an ideal biopolymer offer modern-day researchers' reasons to exploit these to form high-order supramolecular assemblies. These structures could range from simple to complex and provide various applications. Among them, supramolecular assemblies like DNA hydrogels (DNA-HG) and DNA dendrimers (DNA-DS) show massive growth potential in the areas of biomedical applications such as cell biology, medical stream, molecular biology, pharmacology, and healthcare product manufacturing. The application of both of these assemblies has seen enormous growth in recent years. In this focused review on DNA-based supramolecular assemblies like hydrogels and dendrimers, we present the principles of synthesis and characterization, key developments with examples and applications, and conclude with a brief perspective on challenges and future outlook for such devices and their subsequent applications.
DNA 是一种带负电荷的亲水性天然生物聚合物，具有可生物降解性、生物相容性、无毒和非免疫原性等特性。这些特性使 DNA 成为一种理想的生物聚合物，为现代研究人员提供了利用这些特性来形成高级超分子组装体的理由。这些结构可以从简单到复杂，提供各种应用。其中，DNA 水凝胶 (DNA-HG) 和 DNA 树状聚合物 (DNA-DS) 等超分子组装体在生物医学应用领域（如细胞生物学、医疗领域、分子生物学、药理学和医疗保健产品制造）显示出巨大的增长潜力。这两种组装体的应用近年来都有了巨大的增长。在本次关于基于 DNA 的超分子组装体（如水凝胶和树状聚合物）的重点综述中，我们介绍了它们的合成和表征原理、带有实例的关键发展和应用，并简要探讨了这些器件及其后续应用的挑战和未来展望。
