College of Computer Engineering, Jimei University, Xiamen, China.
Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Neurol India. 2022 Mar-Apr;70(2):682-688. doi: 10.4103/0028-3886.344667.
Blood-brain barrier (BBB) is frequently disrupted in patients with diabetes mellitus (DM) and/or neurosyphilis (NS). Clinical cases reflect a trend that non-neurosyphilis (non-NS) patients with impaired glucose tolerance (IGT) are likely to develop NS and/or DM.
To investigate whether IGT promotes BBB disruption in patients with non-NS.
A total of 21 subjects were enrolled, including six with IGT, nine with non-NS, and six with both IGT and non-NS. BBB permeability was evaluated by dynamic contrast-enhanced (DCE) MRI and the secretion of biomarkers from cerebrospinal fluid (CSF) were measured by colorimetric method, immune turbidimetric method, and enzyme-linked immunosorbent assay (ELISA) method.
The non-NS patients with IGT have higher BBB permeability at cortex superior frontal gyrus, white matter, and thalamus than non-NS patients without IGT or IGT patients without non-NS. The CSF-serum albumin-quotient (Qalb) levels and CSF secretion are highest in non-NS patients with IGT, including matrix metalloproteinase 9 (MMP9), soluble intercellular cell adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1).
Significant correlations between CSF biomarkers and BBB permeability were found.
糖尿病（DM）和/或神经梅毒（NS）患者的血脑屏障（BBB）经常受损。临床病例反映出一种趋势，即糖耐量受损（IGT）的非神经梅毒（非 NS）患者可能会发展为 NS 和/或 DM。
探讨 IGT 是否会促进非 NS 患者的 BBB 破坏。
共纳入 21 名受试者，包括 6 名 IGT 患者、9 名非 NS 患者和 6 名同时患有 IGT 和非 NS 的患者。通过动态对比增强（DCE）MRI 评估 BBB 通透性，并通过比色法、免疫比浊法和酶联免疫吸附测定（ELISA）法测量脑脊液（CSF）中生物标志物的分泌。
与非 NS 患者无 IGT 或 IGT 患者无非 NS 相比，IGT 的非 NS 患者大脑皮质额上回、白质和丘脑的 BBB 通透性更高。CSF-血清白蛋白比率（Qalb）水平和 CSF 分泌在 IGT 的非 NS 患者中最高，包括基质金属蛋白酶 9（MMP9）、可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）。
CSF 生物标志物与 BBB 通透性之间存在显著相关性。
