College of Computer Engineering, Jimei University, Xiamen, 361021, China.
Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.
Neurol Sci. 2020 Jan;41(1):83-90. doi: 10.1007/s10072-019-04031-x. Epub 2019 Aug 22.
Diabetes mellitus (DM) and neurosyphilis (NS) may both damage the blood-brain barrier (BBB). It seems that non-neurosyphilis (non-NS) patients with high HbA levels are likely to develop into NS. However, the correlation of HbA level with BBB disruption in syphilis (non-NS) patients is unclear. In this study, we used dynamic contrast-enhanced (DCE) MRI to quantify regional BBB permeability in syphilis (non-NS) patients and detected several molecular biomarkers of cerebrospinal fluid (CSF). We found that BBB permeability values in the hippocampus, white matter, and cortex inferior temporal gyrus were correlated with albumin quotient (Qalb), CSF concentrations of interleukin IL-6 and IL-10. Moreover, BBB breakdown in white matter was correlated with CSF concentrations of sICAM-1 and sVCAM-1. In conclusion, our data suggest that BBB integrity may be liable to be disrupted in syphilis (non-NS) patients, patients with high HbA levels, as well as syphilis (non-NS) patients with high HbA levels, and it is particularly important to control blood glucose in these patients.
糖尿病（DM）和神经梅毒（NS）都可能损害血脑屏障（BBB）。似乎高 HbA 水平的非神经梅毒（非 NS）患者更有可能发展为 NS。然而，HbA 水平与梅毒（非 NS）患者 BBB 破坏的相关性尚不清楚。在这项研究中，我们使用动态对比增强（DCE）MRI 定量测量梅毒（非 NS）患者的局部 BBB 通透性，并检测了几种脑脊液（CSF）分子生物标志物。我们发现，海马、白质和皮质下颞叶的 BBB 通透性值与白蛋白商（Qalb）、CSF 中白细胞介素 IL-6 和 IL-10 的浓度相关。此外，白质中的 BBB 破坏与 CSF 中 sICAM-1 和 sVCAM-1 的浓度相关。总之，我们的数据表明，梅毒（非 NS）患者、HbA 水平较高的患者以及 HbA 水平较高的梅毒（非 NS）患者的 BBB 完整性可能容易受到破坏，因此控制这些患者的血糖尤为重要。
