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[外周动脉疾病的血管内介入治疗]

[Endovascular interventions for peripheral arterial disease].

作者信息

Steiner Sabine, Schmidt Andrej

机构信息

Klinik und Poliklinik für Angiologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig (AöR), Liebigstr. 20, 04103, Leipzig, Deutschland.

出版信息

Inn Med (Heidelb). 2022 Jun;63(6):584-590. doi: 10.1007/s00108-022-01351-7. Epub 2022 May 9.

Abstract

Successful revascularization of patients with peripheral arterial disease (PAD) requires a comprehensive understanding of the risk population and the available treatment options. Even the urgency of revascularization varies widely depending on the clinical presentation. Patients with intermittent claudication should undergo a structured exercise program before revascularization may become necessary, whereas acute limb ischemia is a medical emergency and must be revascularized within a few hours. Endovascular treatment techniques have evolved rapidly over the past 20 years. New technologies and procedural techniques allow even complex lesions to be successfully treated with endovascular techniques, and most patients can now be treated minimally invasively in line with an "endovascular first" strategy. Bypass surgery remains an important option for patients with advanced disease. The techniques used vary depending on the clinical presentation, location, and complexity of the lesion. Although the evidence for different techniques is limited, a variety of clinical and lesion factors are known to be critical for acute technical success and long-term patency rates. The use of paclitaxel-coated balloons and stents has been shown to significantly reduce restenosis and reintervention rates after femoropopliteal interventions. However, a late mortality signal associated with the use of these devices continues to be debated. After successful intervention, appropriate drug therapy and standardized follow-up should be established to prevent adverse limb events and reduce the high rate of cardiovascular events.

摘要

成功实现外周动脉疾病(PAD)患者的血管再通需要全面了解风险人群和可用的治疗选择。甚至血管再通的紧迫性也因临床表现而异。间歇性跛行患者在可能需要血管再通之前应接受结构化运动计划,而急性肢体缺血是一种医疗紧急情况,必须在数小时内实现血管再通。在过去20年中,血管内治疗技术发展迅速。新技术和操作技术使即使是复杂病变也能通过血管内技术成功治疗,现在大多数患者可以根据“血管内优先”策略进行微创治疗。旁路手术仍然是晚期疾病患者的重要选择。所使用的技术因临床表现、病变位置和复杂性而异。尽管不同技术的证据有限,但已知多种临床和病变因素对急性技术成功和长期通畅率至关重要。已证明使用紫杉醇涂层球囊和支架可显著降低股腘动脉介入术后的再狭窄和再次干预率。然而,与使用这些装置相关的晚期死亡信号仍在争论中。成功干预后,应建立适当的药物治疗和标准化随访,以预防肢体不良事件并降低心血管事件的高发生率。

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