Mandel J S, Schuman L M
J Gerontol. 1987 May;42(3):259-64. doi: 10.1093/geronj/42.3.259.
A case-control study of a number of factors of possible etiologic significance for prostatic cancer was conducted in the Minneapolis-St. Paul area. The focus was primarily on sexual factors. Two hundred and fifty incident cases of prostatic cancer, 238 hospital controls, and 240 neighborhood controls were included. Controls were matched to cases on age, sex, and race. Cases were somewhat more educated than controls. An association was found between prostatic cancer and a history of venereal disease in their sexual partners: odds ratio (OR) = 2.71, 95% confidence interval (CI) = 1.14 to 6.46 and OR = 2.09, 95% CI = 1.02 to 4.29 for hospital and neighborhood controls, respectively. Cases had more sexual experiences with prostitutes, although their overall lifetime frequency of sexual intercourse with all partners was somewhat lower. Cases also reported more homosexual partners than controls. The results from the study lend some support to an infectious hypothesis for prostatic cancer. The lower frequency of sexual intercourse (OR = .54, 95% CI = .34 to .83 and OR = .68, 95% CI = .47 to 1.01 for hospital and neighborhood controls, respectively) is also noteworthy and may be indicative of a hormonal difference related to sexual interest or drive.
在明尼阿波利斯 - 圣保罗地区开展了一项病例对照研究，探究一些可能对前列腺癌具有病因学意义的因素。研究重点主要是性因素。研究纳入了250例前列腺癌新发病例、238名医院对照者和240名社区对照者。对照者在年龄、性别和种族方面与病例进行匹配。病例的受教育程度略高于对照者。研究发现前列腺癌与其性伴侣的性病病史之间存在关联：医院对照者的优势比（OR）= 2.71，95%置信区间（CI）= 1.14至6.46；社区对照者的OR = 2.09，95% CI = 1.02至4.29。病例与妓女有更多性经历，尽管他们与所有伴侣的终生性交总频率略低。病例报告的同性恋伴侣也比对照者多。该研究结果为前列腺癌的感染假说提供了一些支持。性交频率较低（医院对照者的OR = 0.54，95% CI = 0.34至0.83；社区对照者的OR = 0.68，95% CI = 0.47至1.01）也值得注意，可能表明与性兴趣或性欲相关的激素差异。
