Ge Xiaoxiao, Wang Xiao, Shen Peng
Departments of Medical Oncology, Hangzhou, Zhejiang 310000, P.R. China.
Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China.
Biomed Rep. 2013 May;1(3):433-439. doi: 10.3892/br.2013.82. Epub 2013 Mar 19.
Prostate cancer is the second most frequently diagnosed type of cancer and the sixth leading cause of cancer mortality among males worldwide. The aim of this study was to investigate the association between the infection by herpes simplex virus type 2 (HSV-2) or human herpesvirus 8 (HHV-8) and the risk of prostate cancer. A systematic literature search was performed using PubMed, Cochrane Library, Web of Science, Scopus, CNKI and CBM. The association of HSV-2 or HHV-8 infection with the risk of prostate cancer was separately assessed. Estimates of the odds ratio (OR) with 95% confidence interval (CI) were pooled by the fixed- or random-effects model. A total of 11 articles with 2,996 cases and 3,875 controls were included in this meta-analysis. HSV-2 infection was associated with increased prostate cancer risk (OR=1.209; 95% CI, 1.003-1.456). Results of the stratified analysis suggested that such an association existed among participants from North and South America (OR=1.226; 95% CI, 1.000-1.503). No significant correlation was observed in the HHV-8 group (OR=1.106; 95% CI, 0.765-1.598). Further investigations and large-sample studies are required to elucidate the possible mechanism underlying viral carcinogenesis and the association between herpes virus infection and the risk of prostate cancer.
前列腺癌是全球男性中第二常见的诊断癌症类型，也是癌症死亡的第六大主要原因。本研究的目的是调查2型单纯疱疹病毒（HSV - 2）或人类疱疹病毒8（HHV - 8）感染与前列腺癌风险之间的关联。使用PubMed、Cochrane图书馆、科学网、Scopus、中国知网和中国生物医学文献数据库进行了系统的文献检索。分别评估了HSV - 2或HHV - 8感染与前列腺癌风险的关联。通过固定效应或随机效应模型汇总了比值比（OR）及其95%置信区间（CI）的估计值。本荟萃分析共纳入了11篇文章，涉及2996例病例和3875例对照。HSV - 2感染与前列腺癌风险增加相关（OR = 1.209；95% CI，1.003 - 1.456）。分层分析结果表明，在来自北美洲和南美洲的参与者中存在这种关联（OR = 1.226；95% CI，1.000 - 1.503）。在HHV - 8组中未观察到显著相关性（OR = 1.106；95% CI，0.765 - 1.598）。需要进一步的研究和大样本研究来阐明病毒致癌的可能机制以及疱疹病毒感染与前列腺癌风险之间的关联。
