《HautTief 多学科教育计划在银屑病或特应性皮炎患者中的应用：一项随机对照研究》。
HautTief Multidisciplinary Educational Program for Patients with Psoriasis or Atopic Dermatitis: A Randomized Controlled Study.
机构信息
Department of Dermatology, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland.
Epidemiology, Biostatistics and Prevention Institute, University of Zurich (UZH), Zurich, Switzerland.
出版信息
Dermatology. 2022;238(6):1050-1059. doi: 10.1159/000524225. Epub 2022 May 9.
BACKGROUND
Improving health-related quality of life (HRQoL), disease severity, and treatment adherence through patient education is an increasingly important, yet relatively new area in dermatology. This randomized controlled trial aims to contribute to this growing area of research by exploring the effects of a 9-week educational program for patients with chronic skin diseases.
OBJECTIVE
The aim of the study was to evaluate the effect of a multidisciplinary educational program on HRQoL and disease severity in patients with psoriasis or atopic dermatitis (AD).
METHODS
Sixty-four patients with diagnosed psoriasis or AD were recruited from University Hospital Zurich and randomized (1:1) to the intervention or control group. To assess HRQoL, the following self-reported questionnaires were used: Dermatology Life Quality Index (DLQI), Skindex-29, EuroQol-5D (EQ-5D), RAND 36-Item Short Form Survey (SF-36), and Beck Depression Inventory (BDI) to measure depression symptoms. Psoriasis Area and Severity Index (PASI) and the Eczema Area and Severity Index (EASI) were used to capture disease extent. These scores were assessed at four study visits, which were performed at baseline and 3, 6, and 9 months after the start of the program.
RESULTS
At month 6, an improvement of at least 25% in BDI was recorded in 15 (68.2%) of 22 patients in the intervention group and 6 (27.3%) of 22 patients in the control group (difference 40.9%, p = 0.016). 53.3% (16 of 30) of patients achieved an improvement in one subdomain of the SF-36 score (role limitations due to emotional problems) at 6-month follow-up, compared with 23.1% (6 of 26) of those not attending the educational program (difference 30.2%; p = 0.042). No significant differences in DLQI, Skindex-29, EQ-5D, PASI, and EASI between both groups at the three time points were found.
CONCLUSION
An educational program may improve HRQoL and depression status of patients with psoriasis or AD.
背景
通过患者教育来改善与健康相关的生活质量（HRQoL）、疾病严重程度和治疗依从性，是皮肤科领域一个日益重要但相对较新的领域。本随机对照试验旨在通过探索针对慢性皮肤病患者的 9 周教育计划的效果，为这一日益增长的研究领域做出贡献。
目的
本研究旨在评估多学科教育计划对银屑病或特应性皮炎（AD）患者 HRQoL 和疾病严重程度的影响。
方法
从苏黎世大学医院招募了 64 名确诊为银屑病或 AD 的患者，并将其随机（1:1）分配至干预组或对照组。为评估 HRQoL，使用以下自评问卷：皮肤病生活质量指数（DLQI）、Skindex-29、EuroQol-5D（EQ-5D）、RAND 36-Item Short Form Survey（SF-36）和贝克抑郁量表（BDI）来衡量抑郁症状。使用银屑病面积和严重程度指数（PASI）和湿疹面积和严重程度指数（EASI）来衡量疾病程度。这些评分在 4 次研究访视中进行，分别在基线以及方案开始后 3、6 和 9 个月进行评估。
结果
在第 6 个月，干预组 22 名患者中有 15 名（68.2%）和对照组 22 名患者中有 6 名（27.3%）的 BDI 至少改善了 25%（差异 40.9%，p=0.016）。与未参加教育计划的患者（23.1%，6 名/26 名）相比，在 6 个月随访时，有 53.3%（16 名/30 名）的患者在 SF-36 评分的一个亚领域（因情绪问题导致的角色限制）中得到了改善（差异 30.2%；p=0.042）。在三个时间点，两组患者在 DLQI、Skindex-29、EQ-5D、PASI 和 EASI 方面均未发现显著差异。
结论
教育计划可能改善银屑病或 AD 患者的 HRQoL 和抑郁状况。
Zotero 插件