特应性皮炎患者在 COVID-19 大流行前后的总体和皮肤特异性健康相关生活质量。

General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic.

机构信息

Department of Health Economics, Corvinus University of Budapest, Hungary.

From the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University.

出版信息

Dermatitis. 2022;33(6S):S92-S103. doi: 10.1097/DER.0000000000000908. Epub 2022 Jun 8.

DOI:10.1097/DER.0000000000000908

PMID:35674639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9674441/

Abstract

BACKGROUND

Few studies have investigated health-related quality of life (HRQoL) in patients with atopic dermatitis (AD) during the COVID-19 pandemic.

OBJECTIVES

The objectives of this study were to compare HRQoL in adult AD patients before and during the pandemic and to assess measurement performance of 4 HRQoL measures.

METHODS

Between 2018 and 2021, a multicenter, cross-sectional survey was conducted, involving 218 adult AD patients. Health-related quality of life outcomes included the EQ-5D-5L, Skindex-16, Dermatology Life Quality Index (DLQI), and DLQI-Relevant (DLQI-R). Severity was measured using objective SCORing Atopic Dermatitis, Eczema Area and Severity Index, and Investigator Global Assessment.

RESULTS

The mean ± SD EQ-5D-5L utility, Skindex-16, DLQI, and DLQI-R scores were 0.82 ± 0.22, 56.84 ± 27.46, 13.44 ± 8.46, and 13.76 ± 8.60, respectively. The patients reported more problems during the pandemic ( P < 0.05) regarding pain/discomfort (odds ratio [OR], 1.78), worrying (OR, 1.89), concerns about persistence/reoccurrence of disease (OR, 1.88), and social relationships (OR, 1.69). The HRQoL outcomes showed strong correlations with each other (range of rs , |0.69| to |0.99|). The Skindex-16, DLQI, and DLQI-R were able to discriminate between severity groups with large (η 2 = 0.20-0.23), whereas the EQ-5D-5L with moderate effect sizes (η 2 = 0.08-0.11).

CONCLUSIONS

Atopic dermatitis patients experienced significantly more problems in some areas of HRQoL during the pandemic. The EQ-5D-5L, Skindex-16, DLQI, and DLQI-R demonstrated good convergent and known-group validity and can be suitable instruments for HRQoL assessment in clinical and research settings.

摘要

背景

鲜有研究调查过 COVID-19 大流行期间特应性皮炎（AD）患者的健康相关生活质量（HRQoL）。

目的

本研究旨在比较成人 AD 患者在大流行前后的 HRQoL，并评估 4 种 HRQoL 测量方法的测量性能。

方法

2018 年至 2021 年间，进行了一项多中心、横断面调查，纳入了 218 例成年 AD 患者。HRQoL 结局包括 EQ-5D-5L、Skindex-16、皮肤病生活质量指数（DLQI）和 DLQI-相关（DLQI-R）。使用客观 SCORing 特应性皮炎、湿疹面积和严重程度指数和研究者全球评估来衡量严重程度。

结果

平均 ± SD 的 EQ-5D-5L 效用、Skindex-16、DLQI 和 DLQI-R 评分分别为 0.82 ± 0.22、56.84 ± 27.46、13.44 ± 8.46 和 13.76 ± 8.60。患者在大流行期间报告了更多的问题（P<0.05），涉及疼痛/不适（优势比[OR]，1.78）、担忧（OR，1.89）、对疾病持续/复发的担忧（OR，1.88）和社会关系（OR，1.69）。HRQoL 结局彼此之间存在很强的相关性（rs 范围，|0.69|至|0.99|）。Skindex-16、DLQI 和 DLQI-R 能够区分严重程度组，差异具有较大效应量（η 2 = 0.20-0.23），而 EQ-5D-5L 的效应量中等（η 2 = 0.08-0.11）。