Departments of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Clin Chim Acta. 2022 Jun 1;531:368-374. doi: 10.1016/j.cca.2022.05.002. Epub 2022 May 6.
Studies have focused on the search of novel biomarkers that allow to easily identify dysfunctional adipose tissue (AT). Uric acid (UA) could be produced and reabsorbed by AT. It has been suggested that the increases of UA concentrations participates in AT dysfunction. We investigated the association of UA with morpho-functional adipose tissue markers in apparently healthy subjects.
Forty apparently healthy individuals were included. Dietary habits and anthropometrical features were evaluated. Circulating concentrations of UA, adiponectin, leptin, and plasminogen activator inhibitor-1 (PAI-1) were quantified. Periumbilical subcutaneous AT samples were obtained and adipocyte number, adipocyte area, and macrophages content were assessed.
The present study included 40 healthy subjects (67% women) with an average age of 57 ± 9 y, BMI of 26 ± 4 (kg/m). UA showed a significant association with the number and mean area of adipocytes, macrophages number, adiponectin, and PAI-1. Although UA was independently associated with the number and mean area of adipocytes, macrophages number, adiponectin into the adjusted multivariable model.
UA concentrations are associated with morpho-functional adipose tissue markers. Our results underscore the importance of UA as one earlier instigator of adipose tissue dysfunction in subjects without metabolic abnormalities.
研究集中于寻找新型生物标志物，以便能够轻松识别功能失调的脂肪组织 (AT)。尿酸 (UA) 可由 AT 产生和重吸收。有人提出，UA 浓度的增加参与了 AT 功能障碍。我们研究了 UA 与表型健康个体脂肪组织形态功能标志物的相关性。
纳入 40 名表型健康个体。评估了饮食习惯和人体测量特征。定量检测 UA、脂联素、瘦素和纤溶酶原激活物抑制剂-1 (PAI-1) 的循环浓度。采集脐周皮下 AT 样本，评估脂肪细胞数量、脂肪细胞面积和巨噬细胞含量。
本研究包括 40 名健康受试者（67%为女性），平均年龄为 57±9 岁，BMI 为 26±4（kg/m）。UA 与脂肪细胞数量和平均面积、巨噬细胞数量、脂联素和 PAI-1 呈显著相关。尽管 UA 与脂肪细胞数量和平均面积、巨噬细胞数量、脂联素独立相关，但仍纳入调整后的多变量模型。
UA 浓度与脂肪组织形态功能标志物相关。我们的结果强调了 UA 在无代谢异常的个体中作为脂肪组织功能障碍早期引发因素的重要性。
