School of Pharmacy, University of Eastern Finland, Yliopistonranta 1 C, 70211 Kuopio, Finland.
School of Pharmacy, University of Eastern Finland, Yliopistonranta 1 C, 70211 Kuopio, Finland.
Int J Pharm. 2022 Jun 10;621:121800. doi: 10.1016/j.ijpharm.2022.121800. Epub 2022 May 6.
In this study, the intravitreal pharmacokinetics of nanomaterials were investigated in vivo in rats and rabbits. Impact of particle size and shape (spherical, longitudinal) on ocular particle distribution and elimination was investigated with fundus camera, optical coherence tomography and ocular fluorophotometry. Differently sized particles showed prolonged ocular retention and remarkable differences in vitreal elimination, but size dependence was consistent, suggesting that other features have influence on their vitreal kinetics. We also demonstrate that liposomes are eliminated from the rabbit vitreous mainly via the anterior route. Simulation of drug concentrations after injection of intravitreal particles shows the importance of synchronized particle retention and drug release rate for efficient drug delivery. In conclusion, we provide kinetic insights in intravitreally administered nanoparticles to improve retinal drug delivery.
本研究在大鼠和兔体内研究了纳米材料的眼内药代动力学。通过眼底相机、光学相干断层扫描和眼荧光光度法研究了粒径和形状（球形、纵向）对眼部颗粒分布和消除的影响。不同大小的颗粒表现出延长的眼部滞留时间和显著不同的玻璃体消除差异，但尺寸依赖性是一致的，这表明其他特征对其玻璃体动力学有影响。我们还证明脂质体主要通过前途径从兔玻璃体中消除。玻璃体腔内颗粒注射后药物浓度的模拟表明，颗粒滞留和药物释放率的同步对有效药物输送的重要性。总之，我们提供了关于眼内给予的纳米颗粒的动力学见解，以改善视网膜药物输送。
