Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
BMJ Open. 2022 May 9;12(5):e058353. doi: 10.1136/bmjopen-2021-058353.
To systematically assess the sero-prevalence and associated factors of major infectious pathogens in China, where there are high incidence rates of certain infection-related cancers.
Cross-sectional study.
10 (5 urban, 5 rural) geographically diverse areas in China.
A subcohort of 2000 participants from the China Kadoorie Biobank.
Sero-prevalence of 19 pathogens using a custom-designed multiplex serology panel and associated factors.
Of the 19 pathogens investigated, the mean number of sero-positive pathogens was 9.4 (SD 1.7), with 24.4% of participants being sero-positive for >10 pathogens. For individual pathogens, the sero-prevalence varied, being for example, 0.05% for HIV, 6.4% for human papillomavirus (HPV)-16, 53.5% for () and 99.8% for Epstein-Barr virus . The sero-prevalence of human herpesviruses (HHV)-6, HHV-7 and HPV-16 was higher in women than men. Several pathogens showed a decreasing trend in sero-prevalence by birth cohort, including hepatitis B virus (HBV) (51.6% vs 38.7% in those born <1940 vs >1970), HPV-16 (11.4% vs 5.4%), HHV-2 (15.1% vs 8.1%), (65.6% vs 28.8%) and (22.0% vs 9.0%). Across the 10 study areas, sero-prevalence varied twofold to fourfold for HBV (22.5% to 60.7%), HPV-16 (3.4% to 10.9%), (16.2% to 71.1%) and (32.5% to 66.5%). Participants with chronic liver diseases had >7-fold higher sero-positivity for HBV (OR=7.51; 95% CI 2.55 to 22.13).
Among Chinese adults, previous and current infections with certain pathogens were common and varied by area, sex and birth cohort. These infections may contribute to the burden of certain cancers and other non-communicable chronic diseases.
系统评估中国主要传染病病原体的血清流行率及其相关因素，因为中国某些与感染相关的癌症发病率很高。
横断面研究。
中国 10 个（5 个城市，5 个农村）地理位置不同的地区。
中国慢性病前瞻性研究的一个亚队列，共 2000 名参与者。
使用定制的多重血清学检测面板检测 19 种病原体的血清流行率及其相关因素。
在所调查的 19 种病原体中，平均有 9.4 种（标准差 1.7）血清学阳性病原体，24.4%的参与者感染 10 种以上病原体。对于个别病原体，血清流行率有所不同，例如 HIV 为 0.05%，HPV-16 为 6.4%， 为 53.5%，EB 病毒为 99.8%。HHV-6、HHV-7 和 HPV-16 的血清流行率在女性中高于男性。几种病原体的血清流行率呈出生队列下降趋势，包括乙型肝炎病毒（HBV）（1940 年以前出生的人群为 51.6%，1970 年以后出生的人群为 38.7%）、HPV-16（11.4%，5.4%）、HHV-2（15.1%，8.1%）、 （65.6%，28.8%）和 （22.0%，9.0%）。在这 10 个研究地区，HBV（22.5%至 60.7%）、HPV-16（3.4%至 10.9%）、 （16.2%至 71.1%）和 （32.5%至 66.5%）的血清流行率相差两倍至四倍。慢性肝病患者的 HBV 血清阳性率高出 7 倍（OR=7.51；95%CI 2.55 至 22.13）。
在中国成年人中，以前和现在感染某些病原体很常见，且流行率因地区、性别和出生队列而异。这些感染可能是某些癌症和其他非传染性慢性疾病负担的原因。
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