Department of Neurosurgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China; Centre of Neurological and Metabolic Research, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Neuroendocrinology Group, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Australia.
Trends Endocrinol Metab. 2022 Jul;33(7):451-462. doi: 10.1016/j.tem.2022.04.003. Epub 2022 May 7.
Cognitive dysfunction is a common adverse consequence of traumatic brain injury (TBI). After brain injury, the brain and other organs trigger a series of complex metabolic changes, including reduced glucose metabolism, enhanced lipid peroxidation, disordered neurotransmitter secretion, and imbalanced trace element synthesis. In recent years, several research and clinical studies have demonstrated that brain metabolism directly or indirectly affects cognitive dysfunction after TBI, but the mechanisms remain unclear. Drugs that improve the symptoms of cognitive dysfunction caused by TBI are under investigation and treatments that target metabolic processes are expected to improve cognitive function in the future. This review explores the impact of metabolic disorders on cognitive dysfunction after TBI and provides new strategies for the treatment of metabolic disorders.
认知功能障碍是创伤性脑损伤（TBI）的常见不良后果。脑损伤后，大脑和其他器官会引发一系列复杂的代谢变化，包括葡萄糖代谢降低、脂质过氧化增强、神经递质分泌紊乱和微量元素合成失衡。近年来，多项研究和临床研究表明，脑代谢直接或间接影响 TBI 后的认知功能障碍，但机制尚不清楚。目前正在研究改善 TBI 引起的认知功能障碍症状的药物，针对代谢过程的治疗方法有望改善认知功能。本综述探讨了代谢紊乱对 TBI 后认知功能障碍的影响，并为代谢紊乱的治疗提供了新策略。
