细胞周期进程中的代谢波动。
Metabolic oscillations during cell-cycle progression.
机构信息
Université de Caen Normandie (UNICAEN), INSERM U1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, Caen, France; Service of Thoracic Surgery, Cochin Hospital, Assistance Publique - Hopitaux de Paris (APHP), Paris, 75014, France.
Department of Infection, Immunity and Inflammation, Cochin Institute, INSERM U1016, CNRS UMR8104, University of Paris, Paris, 75014, France.
出版信息
Trends Endocrinol Metab. 2022 Jul;33(7):447-450. doi: 10.1016/j.tem.2022.04.006. Epub 2022 May 7.
We discuss how metabolism changes during different phases of the cell cycle to sustain biosynthesis and replication in normal and cancer cells. We also highlight how several master regulators of cell cycle, such as cyclin-cyclin-dependent kinases (cyc-CDK complexes) and E3 proteasome ligases, modulate key metabolic enzymes to support cell-cycle progression.
我们讨论了代谢在细胞周期的不同阶段如何变化，以维持正常细胞和癌细胞中的生物合成和复制。我们还强调了细胞周期的几个主要调节因子，如细胞周期蛋白-细胞周期蛋白依赖性激酶（cyc-CDK 复合物）和 E3 蛋白酶体连接酶，如何调节关键代谢酶以支持细胞周期进程。
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