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分泌多巴胺的嗜铬细胞瘤的麻醉管理。

Anaesthetic management of a dopamine-secreting phaeochromocytoma.

机构信息

Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

出版信息

Rev Esp Anestesiol Reanim (Engl Ed). 2022 Apr;69(4):249-252. doi: 10.1016/j.redare.2020.12.009. Epub 2022 May 6.

Abstract

Pheochromocytomas are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla. Most adrenal pheochromocytomas secrete norepinephrine and epinephrine. Dopamine secreting pheochromocytomas are extremely rare and differs from classic pheochromocytomas in clinical features, posing a significant diagnostic challenge. A 41-year-old women presented to our emergency department because of acute flank colic pain and normotension. The screening abdominal computed tomography scan revealed a left adrenal mass. The laboratory test showed significantly increase in plasma dopamine and 24-h urine dopamine. During surgical removal the patient remained hypotensive requiring doses of norepinephrine. The patient presented significant hypertensive responde during direct laryngoscopy and intubation.

摘要

嗜铬细胞瘤是一种罕见的神经内分泌肿瘤,起源于肾上腺髓质的嗜铬细胞。大多数肾上腺嗜铬细胞瘤分泌去甲肾上腺素和肾上腺素。多巴胺分泌性嗜铬细胞瘤极为罕见,在临床特征上与经典嗜铬细胞瘤不同,这给诊断带来了很大的挑战。一位 41 岁的女性因急性腰部绞痛和血压正常来到我院急诊科就诊。腹部 CT 平扫提示左侧肾上腺肿块。实验室检查显示血浆多巴胺和 24 小时尿多巴胺明显升高。手术切除过程中患者持续低血压,需要给予去甲肾上腺素。在直接喉镜检查和插管过程中,患者表现出明显的高血压反应。

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