Herrera-Acosta J, Gabbai F B, Tapia E, Cermeño J L, Calleja C, Bobadilla N A, Romero L
J Hypertens Suppl. 1986 Dec;4(5):S275-8.
Increased glomerular capillary pressure (GCP) mediates glomerular damage in hypertension. The efficacy of captopril, an angiotensin converting enzyme (ACE) inhibitor, and captopril-hydrochlorothiazide (captopril-TZ) in lowering GCP and preventing glomerular damage was evaluated in rats with two-kidney, one clip (2K, 1C) Goldblatt hypertension and partial ablation of the unclipped kidney. Thirty days after surgery nine rats received captopril, 11 received captopril-TZ and eight served as untreated control rats. Sixty days later systemic hypertension was associated with increased GCP and severe structural damage in the unclipped kidney of C rats. Captopril lowered arterial pressure (AP), and prevented the rise in GCP and structural lesion. Captopril-TZ decreased AP and GCP to a greater extent, but did not reduce structural damage further. Captopril lowered GCP, preventing structural damage; greater reduction of GCP with captopril-TZ did not provide further protection.
肾小球毛细血管压力（GCP）升高介导高血压中的肾小球损伤。在双肾单夹（2K，1C）戈德布拉特高血压大鼠及未夹闭肾部分切除的大鼠中，评估了血管紧张素转换酶（ACE）抑制剂卡托普利及卡托普利 - 氢氯噻嗪（卡托普利 - TZ）降低GCP及预防肾小球损伤的疗效。术后30天，9只大鼠接受卡托普利治疗，11只接受卡托普利 - TZ治疗，8只作为未治疗的对照大鼠。60天后，全身性高血压与C组大鼠未夹闭肾的GCP升高及严重结构损伤相关。卡托普利降低动脉压（AP），并预防GCP升高及结构病变。卡托普利 - TZ在更大程度上降低AP和GCP，但未进一步减轻结构损伤。卡托普利降低GCP，预防结构损伤；卡托普利 - TZ更大程度地降低GCP并未提供进一步保护。
