Bharath Kumar Chandrashekaraiah, Goel Ashish, Jaleel Rajeeb, David Deepu, Zachariah Uday, Ramachandran Jeyamani, Eapen Chundamannil E
Department of Gastroenterology, Division of GI Sciences, CMC Hospital, Vellore, Tamil Nadu, India.
Department of Hepatology, Division of GI Sciences, CMC Hospital, Vellore, Tamil Nadu, India.
J Clin Exp Hepatol. 2022 Mar-Apr;12(2):492-502. doi: 10.1016/j.jceh.2021.05.008. Epub 2021 Jun 16.
To study the prevalence of risk factors for nonalcoholic fatty liver disease (NAFLD) in middle-aged (40-59 years) and elderly patients (≥60 years) with cryptogenic cirrhosis as compared to those with hepatitis B or C virus (HBV or HCV) related cirrhosis.
Between August 2013 and December 2014, cases (cryptogenic cirrhosis) and controls (HBV/HCV cirrhosis) above 40 years of age were prospectively recruited and assessed for the cause and prevalence of risk factors for NAFLD.
One hundred eighteen cases (male-74%; age 55 (40-74) years; median (range); Child's class A:B:C-46:38:16) and 59 controls (male-80%; age 55.5 (40-69) years; Child's class A:B:C-56:30:14) were enrolled. Obesity (53% v/s 39%, -0.081), diabetes mellitus (DM) (52% v/s 27%; -0.002), family history of DM (30% v/s 13%; -0.016), family history of Obesity (21% v/s 3.5%; -0.002) and metabolic syndrome (65% v/s 44%; -0.01) were more among cases than controls. Lifetime weight as obese was also longer in cases than in controls (5.9 ± 6.2 years v/s 3.2 ± 5.1 years, -0.002). On subgroup analysis, in elderly age group, DM (55% v/s 17%, -0.006), family history of DM (40% v/s 11%, -0.025), metabolic syndrome (76% v/s 44%, -0.017) and family history of obesity (19% v/s 0, -0.047) were more common in cases as compared to controls, where as in the middle-age group, family history of obesity was the only significant factor (22% v/s 5%, -0.025). Lifetime weight as obese was longer in cases than controls in both middle and elderly age groups.
Among middle-aged and elderly patients with cirrhosis, there was a higher prevalence of risk factors for NAFLD in those with cryptogenic cirrhosis, compared to those with HBV or HCV cirrhosis.
研究中年（40 - 59岁）和老年（≥60岁）隐源性肝硬化患者与乙型或丙型肝炎病毒（HBV或HCV）相关性肝硬化患者相比，非酒精性脂肪性肝病（NAFLD）危险因素的患病率。
2013年8月至2014年12月期间，前瞻性招募40岁以上的病例（隐源性肝硬化）和对照（HBV/HCV肝硬化），并评估NAFLD危险因素的病因和患病率。
共纳入118例病例（男性占74%；年龄55（40 - 74）岁；中位数（范围）；Child分级A:B:C为46:38:16）和59例对照（男性占80%；年龄55.5（40 - 69）岁；Child分级A:B:C为56:30:14）。病例组肥胖（53%对39%，-0.081）、糖尿病（DM）（52%对27%；-0.002）、DM家族史（30%对13%；-0.016）、肥胖家族史（21%对3.5%；-0.002）和代谢综合征（65%对44%；-0.01）的患病率高于对照组。病例组肥胖持续时间也长于对照组（5.9±6.2年对3.2±5.1年，-0.002）。亚组分析显示，在老年年龄组中病例组DM（55%对17%，-0.006）、DM家族史（40%对11%，-0.025）、代谢综合征（76%对44%，-0.017）和肥胖家族史（19%对0，-0.047）比对照组更常见，而在中年年龄组中，肥胖家族史是唯一显著因素（22%对5%，-0.025）。中年和老年年龄组病例组肥胖持续时间均长于对照组。
在中年和老年肝硬化患者中，与HBV或HCV肝硬化患者相比，隐源性肝硬化患者NAFLD危险因素的患病率更高。
